Browse treatments

AKT inhibitor 

capivasertib based treatment 

capivasertib plus paclitaxel  3 studies   la/mBC - HR-positive - 1st line (L1) mBC - Triple negative (TNBC) - 1st Line (L1) mBC - TNBC - L1 - all population

ipatasertib based treatment 

ipatasertib plus paclitaxel  2 studies   la/mBC - HR positive - L1 - PIK3CA mutant mBC - TNBC - L1 - all population

antibody–drug conjugate 

enfortumab vedotin-ejfv  1 studies   urothelial cancer (UC) - bladder cancer (BC)

sacituzumab govitecan  4 studies   urothelial cancer (UC) - bladder cancer (BC) mBC-Triple negative (TNBC) - 2nd Line (L2)

tisotumab vedotin-tftv  1 studies   cervical cancer (CC)

trastuzumab deruxtecan  4 studies   gastric or gastroesophageal junction cancer (GC) lung cancer : non small cell (NSCLC) metastatic/advanced - breast cancer (mBC) la/mBC - HER2 positive - 2nd Line (L2)

trastuzumab emtansine  9 studies   es-BC - HER2 positive - (neo)adjuvant (NA) es-BC - HR positive - (neo)adjuvant (NA) la/mBC - HER2 positive - 2nd Line (L2) breast cancer - adjuvant

trastuzumab emtasine plus endocrine therapy  3 studies   breast cancer - adjuvant es-BC - HER2 positive - (neo)adjuvant (NA) es-BC - HR positive - (neo)adjuvant (NA)

aurora kinase inhibitors 

alisertib plus paclitaxel  1 studies   la/mBC - HR-positive - 2nd line (L2)

biguanide 

metformin  1 studies   la/mBC - HR-positive - 2nd line (L2)

bispecific antibody 

mirvetuximab soravtansine-gynx  1 studies   ovarian cancer (OC)

teclistamab-cqyv  1 studies   multiple myeloma

celecoxib plus endocrine therapy  1 studies   la/mBC - HR-positive - 2nd line (L2)

chemotherapy 

antifolates 

pralatrexate  1 studies   mNSCLC - L2 - all population

non platinum-based chemotherapy 

alkylating agents 

lurbinectedin  1 studies   lung cancer : small cell (SCLC)

anti CD20 protein 

rituximab based treatment 

rituximab alone  43 studies   neutropenia

microtubul inhibitor 

eribulin  1 studies   la/mBC - HR positive

nucleoside analogues (pyrimidine/purine) 

5FU  2 studies   biliary tract cancer (BTC)

capecitabine  2 studies   mCRC - 2nd line (L2)

taxanes 

paclitaxel 

nab-paclitaxel  4 studies   mBC - Triple negative (TNBC) - 1st Line (L1)

paclitaxel followed by doxorubicin plus cyclophosphamide  4 studies   es-BC - TNBC - NA - all population es-BC - HER2 positive - (neo)adjuvant (NA)

topoisomerase I inhibitor 

irinotecan 

pegylated liposomal doxorubicin and cyclophosphamide  3 studies   breast cancer - triple negative metastatic la/mBC - HR positive - L2 - all population

platinum-based chemotherapy 

platinum derivate 

platinum association 

paclitaxel plus carboplatin 

Standard of Care (SoC) 

cyclin inhibitor 

abemaciclib based treatment 

abemaciclib plus aromatase inhibitor  1 studies   la/mBC - HR-positive - 1st line (L1)

abemaciclib plus BSC  1 studies   mNSCLC - L2 - KRAS mutant

abemaciclib plus endocrine therapy  2 studies   la/mBC - HR-positive - 1st line (L1) breast cancer - adjuvant

abemaciclib plus fulvestrant  1 studies   la/mBC - HR-positive - 2nd line (L2)

abemaciclib plus trastuzumab  1 studies   la/mBC - HER2 positive - 2nd Line (L2)

abemaciclib plus trastuzumab plus fulvestrant  1 studies   la/mBC - HER2 positive - 2nd Line (L2)

dalpiciclib plus fulvestrant  1 studies   la/mBC - HR-positive - 2nd line (L2)

palbociclib based treatment 

palbociclib  1 studies   breast cancer - adjuvant

palbociclib plus endocrine therapy  3 studies   la/mBC - HR positive la/mBC - HR-positive - 1st line (L1) breast cancer - adjuvant

palbociclib plus fulvestrant  3 studies   la/mBC - HR-positive - 2nd line (L2)

palbociclib plus letrozole  2 studies   la/mBC - HR-positive - 1st line (L1)

ribociclib based treatment 

ribociclib plus endocrine therapy  1 studies   la/mBC - HR-positive - 2nd line (L2)

ribociclib plus fulvestrant  1 studies   la/mBC - HR-positive - 2nd line (L2)

ribociclib plus letrozole  1 studies   la/mBC - HR-positive - 1st line (L1)

endocrine therapy 

androgen deprivation therapy (ADT) 

abiraterone plus ADT  2 studies   metastatic, hormone-sensitive prostate cancer

abiraterone plus docetaxel plus ADT  1 studies   metastatic, hormone-sensitive prostate cancer

apalutamide plus ADT  1 studies   metastatic, hormone-sensitive prostate cancer

darolutamide plus doxetaxel plus ADT  1 studies   metastatic, hormone-sensitive prostate cancer

docetaxel plus ADT  4 studies   metastatic, hormone-sensitive prostate cancer

enzalutamide 

enzalutamide plus ADT  2 studies   metastatic, hormone-sensitive prostate cancer

orteronel  1 studies   metastatic, hormone-sensitive prostate cancer

gene alteration target therapy 

ALK inhibitors 

alectinib  2 studies   lung cancer : non small cell (NSCLC)

brigatinib  1 studies   lung cancer : non small cell (NSCLC)

ceritinib  1 studies   lung cancer : non small cell (NSCLC)

crizotinib   3 studies   myofibroblastic tumors lung cancer : non small cell (NSCLC)

BRAF gene alteration targeted therapy 

BRAF inhibitor 

combined BRAF-MEK inhibitors 

encorafenib plus binimetinib  2 studies   colorectal cancer (CRC) melanoma (ML)

trametinib plus dabrafenib 

EGFR gene alteration 

amivantamab-vmjw  5 studies   lung cancer : non small cell (NSCLC) EGFR exon 20 insertion mutation EGFR gene alteration defined cancer

mobocertinib  2 studies   lung cancer : non small cell (NSCLC) EGFR exon 20 insertion mutation

osimertinib  6 studies   eNSCLC - NA - EGFR mutant mNSCLC - L2 - EGFR mutant mNSCLC - L1 - all population

FGFR (2/3) gene alteration targeted therapy 

erdafitinib  3 studies   urothelial cancer (UC) - bladder cancer (BC) FGFR (2/3) gene alteration defined cancer

futibatinib  1 studies   cholangiocarcinoma

infigratinib  3 studies   biliary tract cancer (BTC) cholangiocarcinoma FGFR (2/3) gene alteration defined cancer

pemigatinib  1 studies   cholangiocarcinoma

KRAS gene alteration targeted therapy 

adagrasib  1 studies   lung cancer : non small cell (NSCLC)

sotorasib  6 studies   metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) lung cancer : non small cell (NSCLC) KRAS gene alteration defined cancer

MET gene alteration targeted therapy 

capmatinib  2 studies   lung cancer : non small cell (NSCLC)

savolitinib  1 studies   lung cancer : non small cell (NSCLC)

tepotinib  2 studies   lung cancer : non small cell (NSCLC)

NTRK gene alteration targeted therapy 

entrectinib  1 studies   lung cancer : non small cell (NSCLC)

larotrectinib  5 studies   lung cancer : non small cell (NSCLC) NTRK gene alteration

RET gene alteration targeted therapy 

pralsetinib  3 studies   lung cancer : non small cell (NSCLC) RET gene alteration defined cancer

retifanlimab-dlwr  1 studies   A EFFACER all cancer

selpercatinib  6 studies   lung cancer : non small cell (NSCLC) RET gene alteration defined cancer thyroid cancer

ROS1 and TRK TKI 

repotrectinib  1 studies   lung cancer : non small cell (NSCLC)

selumetinib  1 studies   neurofibroma

HDAC inhibitor 

entinostat plus exemestane  2 studies   la/mBC - HR-positive - 2nd line (L2)

tucidinostat based treatment 

tucidinostat plus exemestane  1 studies   la/mBC - HR-positive - 2nd line (L2)

HER inhibitor 

EGFR inhibitor 

afatinib based treatment 

afatinib alone  4 studies   mNSCLC - L1 - EGFR mutant non squamous - mNSCLC - L2 - all population

afatinib plus BSC  1 studies   mNSCLC - L2 - all population

afatinib plus paclitaxel  1 studies   mNSCLC - L2 - all population

afatinib plus vinorelbine  1 studies   la/mBC - HER2 positive - 2nd Line (L2)

dacomitinib  6 studies   mNSCLC - L2 - KRAS wild type mNSCLC - L2 - all population mNSCLC - L1 - EGFR mutant EGFR gene alteration defined cancer

erlotinib based treatment 

erlotinib alone  25 studies   mNSCLC - L1 - all population mNSCLC - L2 - EGFR wild type mNSCLC - L1 - EGFR mutant laNSCLC - NA - all population mNSCLC - M - EGFR wild type metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - all population mNSCLC - NA - all population mNSCLC - M - all population early NSCLC - (neo)adjuvant (NA)

erlotinib followed by gemcitabine plus platin  1 studies   mNSCLC - M - all population

erlotinib plus bevacizumab  3 studies   non squamous - mNSCLC - L1 - all population mNSCLC - M - EGFR mutant

erlotinib plus cisplatin and gemcitabine  2 studies   mNSCLC - L1 - all population

erlotinib plus gemcitabine  1 studies   mNSCLC - L2 - all population

erlotinib plus pemetrexed  2 studies   mNSCLC - L2 - all population non squamous - mNSCLC - L1 - all population

erlotinib plus SoC  3 studies   mNSCLC - NA - all population metastatic/adv NSCLC (mNSCLC) - maintenance (M) mNSCLC - L1 - all population

tivantinib plus erlotinib  1 studies   mNSCLC - L2 - KRAS mutant

gefitinib based treatment 

gefitinib alone  20 studies   metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - all population mNSCLC - NA - all population non squamous - mNSCLC - L2 - wild type (WT) eNSCLC - NA - EGFR mutant mNSCLC - L1 - all population mNSCLC - L2 - EGFR high mNSCLC - M - all population mNSCLC - L1 - EGFR mutant laNSCLC - NA - all population

gefitinib plus BSC  2 studies   mNSCLC - L1 - all population mNSCLC - L2 - all population

gefitinib plus pemetrexed plus platin  2 studies   metastatic/adv NSCLC (mNSCLC) - maintenance (M)

gefitinib plus SoC (rechallenge)  1 studies   mNSCLC - L2 - EGFR mutant

pemetrexed plus platin followed by maintenance gefitinib  1 studies   non squamous - mNSCLC - L1 - all population

SoC followed by gefitinib  1 studies   mNSCLC - L1 - all population

icotinib  1 studies   mNSCLC - L2 - all population

naquotinib  1 studies   mNSCLC - L1 - EGFR mutant

nimotuzumab based treatment 

nimotuzumab plus gefitinib  1 studies   mNSCLC - L2 - all population

HER2 inhibitor 

neratinib based treatment 

neratinib  2 studies   la/mBC - HER2 positive - 2nd Line (L2) breast cancer - adjuvant

neratinib plus capecitabine  2 studies   la/mBC - HER2 positive - 2nd Line (L2)

pertuzumab based treatment 

pertuzumab plus trastuzumab  6 studies   la/mBC - HER2 positive - 1st Line (L1) breast cancer - adjuvant es-BC - HER2 positive - (neo)adjuvant (NA)

pertuzumab plus trastuzumab plus docetaxel  2 studies   la/mBC - HER2 positive - 1st Line (L1)

trastuzumab based treatment 

docetaxel plus carboplatin with trastuzumab followed by trastuzumab  1 studies   breast cancer - adjuvant

doxorubicin plus cyclophosphamide followed by docetaxel plus trastuzumab  2 studies   breast cancer - adjuvant

trastuzumab  1 studies   la/mBC - HER2 positive - 1st Line (L1)

trastuzumab followed by lapatinib  1 studies   la/mBC - HER2 positive

trastuzumab plus chemotherapy  1 studies   la/mBC - HER2 positive - (neo)adjuvant (NA)

trastuzumab plus endocrine therapy  2 studies   la/mBC - HER2 positive - 1st Line (L1) la/mBC - HR-positive - 1st line (L1)

trastuzumab plus epirubicin and cyclophosphamide followed by docetaxel  1 studies   es-BC - HER2 positive - (neo)adjuvant (NA)

tucatinib based treatment 

tucatinib plus trastuzumab plus capecitabine  2 studies   la/mBC - HER2 positive - 2nd Line (L2)

TKI anti HER1/EGFR and HER2/neu 

lapatinib based treatment 

lapatinib  4 studies   la/mBC - HER2 positive es-BC - HER2 positive - (neo)adjuvant (NA) breast cancer - adjuvant la/mBC - HER2 positive - 2nd Line (L2)

lapatinib plus capecitabine  2 studies   la/mBC - HER2 positive - 2nd Line (L2)

lapatinib plus fulvestrant  1 studies   la/mBC - HR-positive - 1st line (L1)

lapatinib plus letrozole  2 studies   la/mBC - HR-positive - 1st line (L1)

lapatinib plus paclitaxel  1 studies   la/mBC - HER2 positive - (neo)adjuvant (NA)

lapatinib plus trastuzumab  2 studies   la/mBC - HER2 positive la/mBC - HER2 positive - 2nd Line (L2)

lapatinib plus trastuzumab plus paclitaxel  1 studies   la/mBC - HER2 positive - (neo)adjuvant (NA)

HIF-2α inhibitor  1 studies   renal cell cancer (RCC)

IGF-1R inhibitors 

dalotuzumab plus ridaforolimus plus exemestane  1 studies   la/mBC - HR-positive - 1st line (L1)

ganitumab plus endocrine therapy  1 studies   la/mBC - HR-positive - 2nd line (L2)

immune chekpoint inhibitors 

anti-CTLA-4 

ipilimumab based treatment 

ipilimumab alone 

Ipilimumab (10 mg/kg)  5 studies   mML - NA - all population mGC or mGEJC - L2 - all population mML - L2 - all population

ipilimumab plus gp100  2 studies   mML - L2 - all population

ipilimumab plus SoC  4 studies   Extensive stage SCLC (Es-SCLC) - 1st Line (L1) squamous - mNSCLC - L1 - all population mML - L2 - all population

ipilimumab followed by nivolumab  1 studies   early NSCLC - 1st line (L1)

tremelimumab  2 studies   malignant mesothelioma (mMS) - 2nd line (L2) mML - L1 - all population

anti-PD-(L)1 

atezolizumab based treatment 

atezolizumab alone  25 studies   breast cancer - triple negative metastatic lung cancer : non small cell (NSCLC) la/mBC - HER2 positive - 2nd Line (L2) mNSCLC - L1 - PDL1 positive mNSCLC - L2 - PDL1 positive mUC - L2 - all population mUC - L2 - PDL1 positive mUC - L1 - all population mRCC - L1 - PDL1 positive metastatic/advanced RCC (mRCC) - 1st line (L1) mCRC - 2nd line (L2) early NSCLC - 1st line (L1) mHNSCC - (neo)adjuvant (NA) metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA) MIBC - NA - all population mNSCLC - L2 - all population

atezolizumab plus bevacizumab  9 studies   mHCC - (neo)adjuvant (NA) mRCC - L1 - PDL1 positive mCRC - 2nd line (L2) mRCC - L1 - PDL1 negative mHCC - 1st line (L1) metastatic/advanced RCC (mRCC) - 1st line (L1)

atezolizumab plus bevacizumab plus carboplatin plus paclitaxel  4 studies   non squamous - mNSCLC - L1 - all population non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced OC (mOC) - 1st line (L1)

atezolizumab plus cabozantinib  2 studies   metastatic/advanced RCC (mRCC) - 2nd line (L2) mHCC - 1st line (L1)

atezolizumab plus carboplatin plus nab-paclitaxel  4 studies   non squamous - mNSCLC - L1 - all population es-BC - TNBC - NA - all population non squamous - mNSCLC - L1 - Wild Type (WT) squamous - mNSCLC - L1 - all population

atezolizumab plus carboplatin plus paclitaxel  2 studies   squamous - mNSCLC - L1 - all population non squamous - mNSCLC - L1 - all population

atezolizumab plus cometinib  3 studies   metastatic/advanced - colorectal cancer (mCRC) mML - L1 - BRAF wild mCRC - 2nd line (L2)

atezolizumab plus FOLFOXIRI plus bevacizumab  1 studies   mCRC - 1st line (L1)

atezolizumab plus nab-paclitaxel  2 studies   mBC - TNBC - L1 - PDL1 positive mBC - TNBC - L1 - all population

atezolizumab plus nab-paclitxel followed by doxorubicin plus cyclophosphamide  2 studies   es-BC - TNBC - NA - PDL1 positive es-BC - TNBC - NA - all population

atezolizumab plus paclitaxel  2 studies   mBC - TNBC - L1 - PDL1 positive mBC - TNBC - L1 - all population

atezolizumab plus pemetrexed and platin  1 studies   non squamous - mNSCLC - L1 - Wild Type (WT)

atezolizumab plus SoC  8 studies   mOC - L1 - PDL1 positive metastatic/advanced - colorectal cancer (mCRC) mML - L1 - BRAF mutant endometrial cancer mOC - L1 - all population mBC - TNBC - L1 - PDL1 positive Extensive stage SCLC (Es-SCLC) - 1st Line (L1) mUC - L1 - all population

avelumab based treatment 

avelumab alone  12 studies   urothelial cancer (UC) - bladder cancer (BC) mGC or mGEJC - M - HER2 neg/PDL1 positive mNSCLC - L2 - all population mUC - M - PDL1 positive mCRC - 2nd line (L2) metastatic/advanced OC (mOC) - 2nd line (L2) laHNSCC - 1st line (L1) es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA) mNSCLC - L2 - PDL1 positive mGC or mGEJC - L2 - all population mGC or mGEJC - M - HER2 negative mUC - M - all population

avelumab plus axitinib  2 studies   metastatic/advanced RCC (mRCC) - 1st line (L1) mRCC - L1 - PDL1 positive

avelumab plus pegylated liposomal doxorubicin  1 studies   metastatic/advanced OC (mOC) - 2nd line (L2)

avelumab plus SoC  2 studies   endometrial cancer metastatic/advanced OC (mOC) - maintenance (M)

camrelizumab based treatment 

camrelizumab alone  2 studies   mBC - Triple negative (TNBC) - 1st Line (L1) mEC - 2nd line (L2)

cemiplimab  3 studies   basal cell carcinoma mNSCLC - L1 - PDL1 positive mNSCLC - L1 - all population

dostarlimab based treatment 

dostarlimab plus soC  2 studies   endometrial cancer

durvalumab based treatment 

durvalumab alone  13 studies   mBC - HER 2 negative lung cancer : non small cell (NSCLC) NSCLC neoadjuvant setting mUC - L1 - all population mNSCLC - L1 - all population mUC - L1 - PDL1 positive mHNSCC - L2 - all population mNSCLC - L1 - PDL1 positive es-BC - TNBC - NA - all population mNSCLC - L2 - PDL1 positive laNSCLC - M - all population

durvalumab plus bevacizumab  1 studies   mHCC - 1st line (L1)

durvalumab plus etoposide and platin  1 studies   Extensive stage SCLC (Es-SCLC) - 1st Line (L1)

durvalumab plus olaparib plus SoC  1 studies   endometrial cancer

durvalumab plus osimertinib  1 studies   mNSCLC - L2 - EGFR mutant

durvalumab plus SoC  3 studies   early NSCLC - (neo)adjuvant (NA) endometrial cancer billiary tract cancer - 1st line (L1)

finotonlimab (SCT-I10A)  1 studies   metastatic-recurrent HNSCC (mHNSCC)

nivolumab based treatment 

nivolumab alone 

nivolumab plus cabozantinib  1 studies   metastatic/advanced RCC (mRCC) - 1st line (L1)

nivolumab plus SoC  9 studies   NSCLC neoadjuvant setting mGC or mGEJC - L1 - HER2 neg/PDL1 positive mNSCLC - L1 - PDL1 negative mCRC - 1st line (L1) mGC or mGEJC - L1 - HER2 negative locally advanced NSCLC - (neo)adjuvant (NA)

nivolumab followed by ipilimumab  1 studies   mML - L1 - all population

pembrolizumab based treatment 

pembrolizumab alone 

pembrolizumab (10mg/kg)  4 studies   mNSCLC - L2 - PDL1 positive mML - L2 - all population

pembrolizumab (10mg/kg) 2 weeks  1 studies   mML - L2 - all population

pembrolizumab (2mg/kg)  3 studies   mNSCLC - L2 - PDL1 positive mML - L2 - all population

pembrolizumab and pemetrexed plus platin  1 studies   non squamous - mNSCLC - L1 - Wild Type (WT)

pembrolizumab plus 5FU plus platin  3 studies   mHNSCC - L1 - PDL1 positive mHNSCC - L1 - all population

pembrolizumab plus axitinib  1 studies   metastatic/advanced RCC (mRCC) - 1st line (L1)

pembrolizumab plus lenalidomide and dexamethasone  1 studies   multiple myeloma - 1st line (L1)

pembrolizumab plus lenvatinib  4 studies   mHCC - 1st line (L1) metastatic/advanced RCC (mRCC) - 1st line (L1) endometrial cancer

pembrolizumab plus paclitxel followed by doxorubicin plus cyclophosphamide  1 studies   es-BC - HER2 negative - (neo)adjuvant (NA)

pembrolizumab plus pomalidomide and dexamethasone  1 studies   multiple myeloma - 2nd line (L2)

pembrolizumab plus SoC  17 studies   endometrial cancer locally advanced NSCLC - (neo)adjuvant (NA) NSCLC neoadjuvant setting mBC - TNBC - L1 - PDL1 positive mBC - TNBC - L1 - all population glioblastoma (GB) endometrial cancer - (neo)adjuvant (NA) mGC or mGEJC - L1 - PDL1 positive mEC - 1st line (L1) mML - L2 - BRAF mutant Extensive stage SCLC (Es-SCLC) - 1st Line (L1) mUC - L1 - all population non squamous - mNSCLC - L1 - Wild Type (WT) squamous - mNSCLC - L1 - all population

sintilimab based treatment 

sintilimab  3 studies   mHCC - (neo)adjuvant (NA) hepatocell cancer (HCC) mHCC - 1st line (L1)

sintillimab plus SoC  1 studies   mNSCLC - L1 - all population

Tislelizumab  5 studies   metastatic/advanced - esophageal cancer (mEC) mHCC - 1st line (L1) eNSCLC - NA - all population lung cancer : non small cell (NSCLC) mNSCLC - L2 - all population

toripalimab  4 studies   mBC - Triple negative (TNBC) - 1st Line (L1) metastatic/advanced RCC (mRCC) - 1st line (L1)

anti-TIGIT 

tiragolumab  3 studies   lung cancer : non small cell (NSCLC) Extensive stage SCLC (Es-SCLC) - 1st Line (L1)

Immune checkpoint association 

durvalumab plus tremelimumab 

durvalumab plus tremelimumab plus SoC  1 studies   Extensive stage SCLC (Es-SCLC) - 1st Line (L1)

nivolumab plus ipilimumab 

nivolumab plus ipilimumab plus SoC  2 studies   mHCC - 1st line (L1) mNSCLC - L1 - all population

pembrolizumab plus ipilimumab  1 studies   mNSCLC - L1 - PDL1 positive

relatlimab plus nivolumab  1 studies   mML - L1 - all population

Immunostimulant 

IRX-2  1 studies   head and neck cancer squamous cell cancer (HNSCC)

vaccine 

AE37 vaccine plus GM-CSF  1 studies   breast cancer (BC)

GP2 vaccine plus GM-CSF  1 studies   breast cancer (BC)

OBI-822/OBI-821 plus cyclophosphamide  1 studies   la/mBC - HR-positive - 2nd line (L2)

inetetamab plus vinorelbine  1 studies   la/mBC - HER2 positive - 2nd Line (L2)

mTOR inhibitors 

everolimus 

lenvatinib plus everolimus  1 studies   metastatic/advanced RCC (mRCC) - 1st line (L1)

sapanisertib plus fulvestrant  2 studies   la/mBC - HR-positive - 2nd line (L2)

phosphoinositide 3-kinase (PI3K) inhibitor 

alpelisib based treatment 

alpelisib  1 studies   PIK3CA-related overgrowth spectrum

alpelisib plus fulvestrant  2 studies   la/mBC - HR-positive - 2nd line (L2)

alpelisib plus letrozole  2 studies   la/mBC - HR positive - (neo)adjuvant (NA)

buparlisib based treatment 

buparlisib plus fulvestrant  4 studies   la/mBC - HR-positive - 2nd line (L2) la/mBC - HR positive la/mBC - HR positive - L2 - PIK3CA mutant la/mBC - HR positive - L2 - all population

buparlisib plus letrozole  1 studies   la/mBC - HR positive - (neo)adjuvant (NA)

taselisib based treatment 

taselisib plus letrozole  1 studies   es-BC - HR-positive - 1st line (L1)

poly ADP-ribose polymerase (PARP) inhibitor 

niraparib  3 studies   endometrial cancer prostate cancer (PC) ovarian cancer (OC)

olaparib  13 studies   ovarian cancer (OC) BRCA1/2 gene alteration defined cancer prostate cancer (PC) urothelial cancer (UC) - bladder cancer (BC) es-BC - TNBC - NA - all population breast cancer - adjuvant mBC - TNBC - L2 - all population

rucaparib  7 studies   prostate cancer (PC) BRCA1/2 gene alteration defined cancer ovarian cancer (OC) metastatic/advanced OC (mOC) - maintenance (M)

talazoparib  1 studies   mBC-Triple negative (TNBC) - 2nd Line (L2)

veliparib plus paclitaxel plus carboplatin  2 studies   mBC - TNBC - L1 - all population

target therapy 

margetuximab based treatment 

margetuximab plus chemotherapy  1 studies   la/mBC - HER2 positive - 2nd Line (L2)

multikinase inhibitor 

nintedanib  1 studies   ovarian cancer (OC)

VEGF(R) inhibitor 

bevacizumab based treatment 

bevacizumab  2 studies   mHCC - 1st line (L1) ovarian cancer (OC)

bevacizumab plus trastuzumab plus docetaxel  1 studies   la/mBC - HER2 positive - 1st Line (L1)

cediranib plus fulvestrant  1 studies   la/mBC - HR-positive - 1st line (L1)

lenvatinib 

lenvatinib in association  3 studies   metastatic/advanced RCC (mRCC) - 1st line (L1) endometrial cancer

ramucirumab 

ramucirumab plus erlotinib  1 studies   mNSCLC - L1 - EGFR mutant

sorafenib 

sorafenib and erlotinib  1 studies   mNSCLC - L1 - all population

vandetanib  2 studies   mNSCLC - L2 - all population