Living meta-analysis and evidence synthesis of therapies for COVID-19

 

• COVID 19 hospitalized
• COVID 19 all comers
• COVID-19 mild to moderate
• COVID-19 severe or critically
• COVID 19 outpatients
• COVID-19 (hospitalized or not)
• COVID-19 prophylaxis (children)
• COVID-19 prophylaxis (excluding children)
• infections other than COVID-19
• Long COVID-19
• preventing respiratory virus transmission
• secondary prevention

 

• adjuvant therapies
• face mask
• anti-inflammatoty and immuno-therapy
• anti-inflammatory therapies
• colchicine
• non-steroidal anti-inflammatory drugs
• corticosteroids
• Immunostimulants drugs
• convalescent plasma treatment
• neutralizing antibody
• bamlanivimab monotherapy
• casirivimab/imdevimab (Ronapreve)
• cilgavimab and tixagevimab (Evusheld)
• sotrovimab (Xevudy; VIR-7831)
• antiviral and associated therapy
• bromhexine
• chloroquine and derivatives
• hydroxychloroquine
• favipiravir
• ivermectin
• lopinavir/ritonavir
• nirmatrelvir / ritonavir (Paxlovid)
• nitazoxanide
• tenofovir/emtricitabine
• tenofovir/emtricitabine plus hydroxychloroquine
• Drugs for acid related disorders
• H2 blockers
• proton pump inhibitors (PPI)
• miscellaneous
• mouthrise and gargling agents
• mouthrinses
• nicotin
• nitric oxide (gas Inhalation or releasing solution)
• povidone-iodine
• previfenon (EGCG)
• PUL-042 inhalation solution
• Oral antidiabetic drugs
• metformin
• Renin-angiotensin-system-acting agents
• angiotensin converting enzyme inhibitors (ACEIs)
• vaccines
• A EFFACER_sequential Immunization
• BCG vaccination
• complete primary vaccine series
• CoVLP (MT-2766, Medicago)
• DNA vaccine
• Zy-Cov-D (Zydus Cadila)
• first booster dose
• mRNA vaccine (any) - first boost
• Comirnaty - first boost
• heterologous prime-boost
• Inactivated virus vaccine
• CoronaVac (SinoVac)
• Covaxin, Bharat Biotech (BBV152)
• Shifa-Pharmed inactivated vaccine
• Sinopharm Beijing (BBIBP-CorV)
• Sinopharm Wuhan
• mRNA vaccine
• Comirnaty (tozinameran - Pfizer/BIONTECH)
• CureVac
• Spikevax (Moderna mRNA-1273 COVID-19 vaccine)
• Non replicating viral vector
• CanSino (Convidecia)
• Covishield (Oxford/AZ formulation)
• Janssen AD26 vaccine (JNJ-78436735)
• Sputnik V (Gam-COVID-Vac)
• Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)
• protein subunit vaccine
• Anhui Zhifei Longcom
• CoVax-19 SpikoGen
• Nuvaxovid (NVX-CoV2373) Novavax
• Sanofi/GSK recombinant protein vaccine
• SCB-2019
• Replicating Viral Vector
• seasonal influenza vaccines
• second booster dose
• mRNA vaccine (any) - second boost
• Comirnaty - second boost
• Spikevax - second boost
• virus-like particles vaccine
• Medicago
• Vitamins
• vitamin C
• All treatment (not recommended)

    Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS) see more...