Living meta-analysis and evidence synthesis of therapies for COVID-19

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RESIST (Sputnik V Gamaleya Research Institute Russia), 2020 NCT04530396

Sputnik V (Gam-COVID-Vac) (n=16501) vs. placebo (n=5476)

randomized controlled trial   high risk of bias

Studied treatment

Gam-COVID-Vac
(0·5 mL/dose) intramuscularly in a prime-boost regimen: a 21-day interval between the first dose (rAd26) and the second dose (rAd5), both vectors carrying the gene for the full-length SARS-CoV-2 glycoprotein S

Control treatment

placebo
2 doses IM (day 0 and day 21 /-2)

Patients

COVID-19 prophylaxis (excluding children)

Method

double blind

25 hospitals and polyclinics in Moscow, Russia

interim analysis without adjustment of type 1 error rate

Remark

interim results