COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 NCT04322123
azithromycin (n=172) vs. standard of care (n=159)
randomized controlled trial
some concerns about risk of bias
azithromycin plus hydroxychloroquine
standard care plus hydroxychloroquine at a dose of 400 mg twice daily plus azithromycin at a dose of 500 mg once daily for 7 days
hydroxychloroquine
standard care plus hydroxychloroquine at a dose of 400 mg twice dailyThe use of glucocorticoids, other immunomodulators, antibiotic agents others than macrolides , and antiviral agents was allowed
3 arms: hydroxychloroquine plus azythromycin, hydroxychloroquine monotherapy and standard of care
COVID-19 mild to moderate
open-label
Brazil, 55 sites
Randomization was performed in blocks of six and was stratified according to the use or nonuse of supplemental oxygen at the time of randomization
Rashad A (AZI vs SoC), 2021
azithromycin (n=107) vs. standard of care (n=99)
randomized controlled trial
some concerns about risk of bias
azithromycin
azithromycin 500 mg/24 h for 7 days
standard of care
3 arms azithromycin, clarithromycin or standard of care