Thalidomide
Thalidomide tablets 100 mg daily for 14 days added to the usual treatment
Usual care
Patients in both groups received methylprednisolone 50 mg intravenously every 12 hours for 3 days andthen daily for 7 days, hydroxychloroquine 200 mg orally every 12 hours for 5 days. Antibiotics were administered based on physician choice (Ceftriaxone, Azithromycin, and Vancomycin). All patients received enoxaparin 40 mg subcutaneously daily during hospitalization.
COVID-19 severe or critically
1- 18-75 year old men and 50-75 year old women admitted in hospital 2-Spo2 less than 85% in admission 3-Clinical symptoms and signs compatible with COVID19 infection and positive PCR test or lung HRCT abnormalities compatible with COVID19 pneumonia 4-No need to intubation in first 24 hour of admission 5-No multiorgan failure at presentation 6- No shock state at presentation 7- Obtained informed consent Exclusion criteria: 1. Hepatic failure (Child Pugh score ≥ C, AST> 5 times of the upper limit normal) 2. Severe renal dysfunction (GFR less than 30cc per min)
Open-label.
Single center, Khorshid hopsital, Isfahan, Iran.
All patients were visited daily by an Internist or Pulmonologist and were followed weekly for 4 weeks using phone calls.