randomized controlled trial
some concerns about risk of bias
hydroxychloroquine
200x2 for 10 days
placebo
COVID-19 severe or critically
double-blind
3 centres, Mexico
pr-specified sample size : 300 vs 300. In mid-July, 2020, the rhythm of recruitment was reduced drastically, due to severalreasons including patient refusal, that of their relatives, or that of their treating physicians,coinciding with the worldwide suspension of several large trials testing HCQ in which no benefitsof the drug were found
REMAP-CAP-HCQ, 2020 NCT02735707
hydroxychloroquine (n=61) vs. standard of care (n=81)
randomized controlled trial
risk of bias NA
hydroxychloroquine
Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge