anticoagulant, curative dose (n=591) vs. anticoagulant, prophylactic dose (n=616)
randomized controlled trial
some concerns about risk of bias
therapeutic anticoagulation with heparin
Therapeutic anticoagulation was administered according to local site protocols for the treatment of acute venous thromboembolism for up to 14 days or recovery
pharmacological thromboprophylaxis as per local usual care
anticoagulant, curative dose (n=191) vs. anticoagulant, prophylactic dose (n=191)
randomized controlled trial
some concerns about risk of bias
full-dose anticoagulation
standard-dose prophylactic anticoagulation
COVID-19 severe or critically
open label
34 centers, United States
2x2 factorial deisgn with clopidogrel or no antiplatelet therapy; recruitment was stopped early in 03/2022 (∼50% planned recruitment) due to waning ICU-level COVID-19 rates