meta|Evidence - COVID-19
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darunavir cobicistat (n=15) vs. standard of care (n=15)
randomized controlled trial high risk of bias
Darunavir and cobicistat
1 pill of darunavir/cobicistat (a single-tablet regimen containing 800 mg of darunavir and 150 mg of cobicistat) per day for 5 days.
Conventional treatments
Patients did not receive oral antiviral drugs.
All the participants received interferon alpha 2b and standard of care as per guideline recommendation in China.
COVID 19 all comers
Diagnosed as pneumonia caused by 2019-ncoV, according to the notice on printing and distributing the diagnosis and treatment plan of pneumonia with new coronavirus infection made by national health commission of the people's republic of China.
Open-label.
Single-center, Shanghai Public Health Clinical Center, China.
After randomization, respiratory samples were collected every 1–2 days until viral clearance. Viral clearance was defined as reverse transcriptase polymerase chain reaction (RT-PCR) negative on at least 2 consecutive oropharyngeal swabs collected at least 1–2 days apart.
Pilot study.
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