Living meta-analysis and evidence synthesis of therapies for COVID-19

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Hashim A, 2020 NCT04591600

ivermectin plus doxycycline (n=70) vs. standard of care (n=70)

randomized controlled trial   some concerns about risk of bias

Studied treatment

ivermectin doxycycline
200ug/kg PO of Ivermectin per day for 2-3 days along with 100mg PO doxycycline twice per day for 5-10 days

Control treatment

standard of care

Patients

COVID 19 hospitalized

Method

single blind

2 centres, Iraq

recovery of COVID-19 patients was based on the disappearance of symptoms, clearance of radiological chest x-ray or Ct-scans, and getting negative PCR results.

Remark

NCT04523831 (Mahmud), 2020 NCT04523831

ivermectin plus doxycycline (n=200) vs. standard of care (n=200)

randomized controlled trial   some concerns about risk of bias

Studied treatment

Ivermectin and Doxycycline
Ivermectin 6 mg, 2 tab stat and Doxycycline 100 mg twice daily for 5 days

Control treatment

standard of care

Patients

COVID-19 mild to moderate

Method

double blind

1 center, Bangladesh

Remark