meta|Evidence - COVID-19
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vitamin C (n=48) vs. standard of care (n=50)
randomized controlled trial some concerns about risk of bias
Ascorbic acid (high dose)
8000 mg of ascorbic acid (to be divided over 2-3 times per day with meals).
Standard of care
Usual care without any study medications.
4 arms: standard of care, ascorbic acid only, zinc only, ascorbic acid and zinc association.
COVID 19 outpatients
Outpatients ≥ 18 years presenting to Cleveland Clinic Health System in Ohio and Florida who test positive for COVID-19 having any of thefollowing symptoms: fever or chills, shortness of breath or difficulty breathing, cough, fatigue, muscle or body Aches, headache, new loss of taste, new loss of smell, congestion or runny nose, nausea, vomiting, diarrhea.
Open-label.
Cleveland Clinic Main Campus Cleveland, Ohio and Florida
Patients were asked to track their systemic illness daily based on symptoms. Patients recorded a questionnaire with only 4 symptoms (ie, fever/chills, shortness of breath, cough, and fatigue) for scores ranging from 0 to 12. For each symptom, the patients assigned a score of 0 to 3 (with 0 indicating no symptoms; 1, mild symptoms; 2, moderate symptoms; and 3, severe symptoms).
The study was stopped for a low conditional power for benefit with no significant difference among the 4 groups for the primary end point.
zinc plus vitamin c (n=58) vs. standard of care (n=50)
randomized controlled trial some concerns about risk of bias
Ascorbic acid (high dose) plus zinc (high dose)
8000 mg of ascorbic acid (to be divided over 2-3 times per day with meals) plus 50mg of zinc gluconate at bedtime.
Standard of care
Usual care without any study medications.
4 arms: standard of care, ascorbic acid only, zinc only, ascorbic acid and zinc association.
COVID 19 outpatients
Outpatients ≥ 18 years presenting to Cleveland Clinic Health System in Ohio and Florida who test positive for COVID-19 having any of thefollowing symptoms: fever or chills, shortness of breath or difficulty breathing, cough, fatigue, muscle or body Aches, headache, new loss of taste, new loss of smell, congestion or runny nose, nausea, vomiting, diarrhea.
Open-label.
Cleveland Clinic Main Campus Cleveland, Ohio and Florida
Patients were asked to track their systemic illness daily based on symptoms. Patients recorded a questionnaire with only 4 symptoms (ie, fever/chills, shortness of breath, cough, and fatigue) for scores ranging from 0 to 12. For each symptom, the patients assigned a score of 0 to 3 (with 0 indicating no symptoms; 1, mild symptoms; 2, moderate symptoms; and 3, severe symptoms).
The study was stopped for a low conditional power for benefit with no significant difference among the 4 groups for the primary end point.
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