meta
|
evidence
oncology
Living systematic review and meta-analysis
AKT inhibitor
capivasertib based treatment
capivasertib plus paclitaxel
ipatasertib based treatment
ipatasertib plus paclitaxel
antibody–drug conjugate
sacituzumab govitecan
trastuzumab deruxtecan
trastuzumab emtansine
trastuzumab emtasine plus endocrine therapy
aurora kinase inhibitors
alisertib plus paclitaxel
biguanide
metformin
celecoxib plus endocrine therapy
chemotherapy
non platinum-based chemotherapy
nucleoside analogues (pyrimidine/purine)
capecitabine
taxanes
paclitaxel
nab-paclitaxel
paclitaxel followed by doxorubicin plus cyclophosphamide
Standard of Care (SoC)
cyclin inhibitor
abemaciclib based treatment
abemaciclib plus aromatase inhibitor
abemaciclib plus endocrine therapy
abemaciclib plus fulvestrant
dalpiciclib plus fulvestrant
palbociclib based treatment
palbociclib
palbociclib plus endocrine therapy
palbociclib plus fulvestrant
palbociclib plus letrozole
ribociclib based treatment
ribociclib plus endocrine therapy
ribociclib plus fulvestrant
ribociclib plus letrozole
endocrine therapy
androgen deprivation therapy (ADT)
abiraterone plus ADT
abiraterone plus docetaxel plus ADT
apalutamide plus ADT
darolutamide plus doxetaxel plus ADT
docetaxel plus ADT
enzalutamide
enzalutamide plus ADT
gene alteration target therapy
BRAF gene alteration targeted therapy
BRAF inhibitor
combined BRAF-MEK inhibitors
trametinib plus dabrafenib
KRAS gene alteration targeted therapy
sotorasib
MET gene alteration targeted therapy
capmatinib
NTRK gene alteration targeted therapy
entrectinib
larotrectinib
RET gene alteration targeted therapy
pralsetinib
selpercatinib
HDAC inhibitor
entinostat plus exemestane
tucidinostat based treatment
tucidinostat plus exemestane
HER inhibitor
EGFR inhibitor
afatinib based treatment
afatinib plus vinorelbine
HER2 inhibitor
neratinib based treatment
neratinib
neratinib plus capecitabine
pertuzumab based treatment
pertuzumab plus trastuzumab
pertuzumab plus trastuzumab plus docetaxel
trastuzumab based treatment
docetaxel plus carboplatin with trastuzumab followed by trastuzumab
doxorubicin plus cyclophosphamide followed by docetaxel plus trastuzumab
trastuzumab plus endocrine therapy
trastuzumab plus epirubicin and cyclophosphamide followed by docetaxel
tucatinib based treatment
tucatinib plus trastuzumab plus capecitabine
TKI anti HER1/EGFR and HER2/neu
lapatinib based treatment
lapatinib
lapatinib plus capecitabine
lapatinib plus fulvestrant
lapatinib plus letrozole
lapatinib plus paclitaxel
lapatinib plus trastuzumab
lapatinib plus trastuzumab plus paclitaxel
IGF-1R inhibitors
dalotuzumab plus ridaforolimus plus exemestane
ganitumab plus endocrine therapy
immune chekpoint inhibitors
anti-CTLA-4
ipilimumab based treatment
ipilimumab alone
Ipilimumab (10 mg/kg)
ipilimumab plus gp100
ipilimumab plus SoC
tremelimumab
anti-PD-(L)1
atezolizumab based treatment
atezolizumab alone
atezolizumab plus bevacizumab
atezolizumab plus bevacizumab plus carboplatin plus paclitaxel
atezolizumab plus cabozantinib
atezolizumab plus carboplatin plus nab-paclitaxel
atezolizumab plus carboplatin plus paclitaxel
atezolizumab plus cometinib
atezolizumab plus FOLFOXIRI plus bevacizumab
atezolizumab plus nab-paclitaxel
atezolizumab plus nab-paclitxel followed by doxorubicin plus cyclophosphamide
atezolizumab plus paclitaxel
atezolizumab plus pemetrexed and platin
atezolizumab plus SoC
avelumab based treatment
avelumab alone
avelumab plus axitinib
avelumab plus pegylated liposomal doxorubicin
avelumab plus SoC
camrelizumab based treatment
camrelizumab alone
cemiplimab
dostarlimab based treatment
dostarlimab plus soC
durvalumab based treatment
durvalumab alone
durvalumab plus bevacizumab
durvalumab plus etoposide and platin
durvalumab plus olaparib plus SoC
durvalumab plus osimertinib
durvalumab plus SoC
nivolumab based treatment
nivolumab alone
nivolumab plus cabozantinib
nivolumab plus SoC
nivolumab followed by ipilimumab
pembrolizumab based treatment
pembrolizumab alone
pembrolizumab (10mg/kg)
pembrolizumab (10mg/kg) 2 weeks
pembrolizumab (2mg/kg)
pembrolizumab and pemetrexed plus platin
pembrolizumab plus 5FU plus platin
pembrolizumab plus axitinib
pembrolizumab plus lenalidomide and dexamethasone
pembrolizumab plus lenvatinib
pembrolizumab plus paclitxel followed by doxorubicin plus cyclophosphamide
pembrolizumab plus pomalidomide and dexamethasone
pembrolizumab plus SoC
sintilimab based treatment
sintilimab
sintillimab plus SoC
Tislelizumab
toripalimab
Immune checkpoint association
durvalumab plus tremelimumab
durvalumab plus tremelimumab plus SoC
nivolumab plus ipilimumab
nivolumab plus ipilimumab plus SoC
pembrolizumab plus ipilimumab
relatlimab plus nivolumab
Immunostimulant
vaccine
AE37 vaccine plus GM-CSF
GP2 vaccine plus GM-CSF
OBI-822/OBI-821 plus cyclophosphamide
inetetamab plus vinorelbine
mTOR inhibitors
everolimus
lenvatinib plus everolimus
sapanisertib plus fulvestrant
phosphoinositide 3-kinase (PI3K) inhibitor
alpelisib based treatment
alpelisib plus fulvestrant
alpelisib plus letrozole
buparlisib based treatment
buparlisib plus fulvestrant
buparlisib plus letrozole
taselisib based treatment
taselisib plus letrozole
poly ADP-ribose polymerase (PARP) inhibitor
niraparib
olaparib
rucaparib
talazoparib
veliparib plus paclitaxel plus carboplatin
target therapy
margetuximab based treatment
margetuximab plus chemotherapy
multikinase inhibitor
nintedanib
VEGF(R) inhibitor
bevacizumab based treatment
bevacizumab
bevacizumab plus trastuzumab plus docetaxel
cediranib plus fulvestrant
lenvatinib
lenvatinib in association
All
A EFFACER all cancer
basal cell carcinoma
biliary tract cancer (BTC)
billiary tract cancer - (neo)adjuvant (NA)
billiary tract cancer - 1st line (L1)
billiary tract cancer - 2nd line (L2)
cholangiocarcinoma
breast cancer (BC)
breast cancer - adjuvant
breast cancer - HER2-positive
es-BC - HER2 positive - (neo)adjuvant (NA)
la/mBC - HER2 positive
la/mBC - HER2 positive - (neo)adjuvant (NA)
la/mBC - HER2 positive - 1st Line (L1)
la/mBC - HER2 positive - 2nd Line (L2)
breast cancer - HR positive
es-BC - HR positive - (neo)adjuvant (NA)
es-BC - HR-positive - 1st line (L1)
la/mBC - HR positive
la/mBC - HR positive - (neo)adjuvant (NA)
la/mBC - HR positive - NA - PIK3CA mutant
la/mBC - HR-positive - 1st line (L1)
la/mBC - HR positive - L1 - PIK3CA mutant
la/mBC - HR-positive - 2nd line (L2)
la/mBC - HR positive - L2 - all population
la/mBC - HR positive - L2 - PIK3CA mutant
breast cancer - triple negative
breast cancer - triple negative metastatic
mBC - Triple negative (TNBC) - (neo)adjuvant (NA)
mBC - Triple negative (TNBC) - 1st Line (L1)
mBC - TNBC - L1 - all population
mBC - TNBC - L1 - PDL1 positive
mBC-Triple negative (TNBC) - 2nd Line (L2)
mBC - TNBC - L2 - all population
mBC - TNBC - L2 - PDL1 positive
es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA)
es-BC - TNBC - NA - all population
es-BC - TNBC - NA - PDL1 positive
es-BC - Triple negatif (TNBC) - 1st line (L1)
breast cancer HER 2 negative
es-BC - HER2 negative - (neo)adjuvant (NA)
mBC - HER 2 negative
metastatic/advanced - breast cancer (mBC)
cervical cancer (CC)
classical Hodgkin lymphoma (cHL)
refractory classic Hodgkin lymphoma (R/R cHL)
R/R cHL - second line or more (L2)
colorectal cancer (CRC)
locally advanced rectal cancer (LARC)
metastatic/advanced - colorectal cancer (mCRC)
mCRC - (neo)adjuvant (NA)
mCRC - 1st line (L1)
mCRC - 2nd line (L2)
endometrial cancer
endometrial cancer - (neo)adjuvant (NA)
esophageal cancer (EC)
locally advanced - esophageal cancer (laEC)
laEC - Neo(adjuvant) (NA)
metastatic/advanced - esophageal cancer (mEC)
mEC - (neo)adjuvant (NA)
mEC - 1st line (L1)
mEC - 2nd line (L2)
gastric or gastroesophageal junction cancer (GC)
locally advanced (laGC)
laGC - (neo)adjuvant (NA)
metastatic/advanced mGC or mGEJC
mGC or mGEJC - 1st line (L1)
mGC or mGEJC - L1 - all population
mGC or mGEJC - L1 - HER2 neg/PDL1 positive
mGC or mGEJC - L1 - HER2 negative
mGC or mGEJC - L1 - HER2 positive
mGC or mGEJC - L1 - PDL1 positive
mGC or mGEJC - 2nd Line (L2)
mGC or mGEJC - L2 - all population
mGC or mGEJC - L2 - PDL1 positive
mGC or mGEJC - maintenance (M)
mGC or mGEJC - M - HER2 negative
mGC or mGEJC - M - HER2 neg/PDL1 positive
gene alteration defined cancer
BRAF gene alteration defined cancer
BRCA1/2 gene alteration defined cancer
EGFR gene alteration defined cancer
EGFR exon 20 insertion mutation
FGFR (2/3) gene alteration defined cancer
KRAS gene alteration defined cancer
MET gene alteration defined cancer
NTRK gene alteration
RET gene alteration defined cancer
glioblastoma (GB)
metastatic glioblastoma (mGB) - 1st line (L1)
metastatic glioblastoma (mGB) - 2nd line (L2)
head and neck cancer squamous cell cancer (HNSCC)
locally advanced (laHNSCC)
laHNSCC - (neo)adjuvant (NA)
laHNSCC - 1st line (L1)
laHNSCC - 2nd line (L2)
metastatic-recurrent HNSCC (mHNSCC)
mHNSCC - (neo)adjuvant (NA)
mHNSCC - 1st line (L1)
mHNSCC - L1 - all population
mHNSCC - L1 - PDL1 positive
mHNSCC - 2nd line (L2)
mHNSCC - L2 - all population
mHNSCC - L2 - PDL1 negative
mHNSCC - L2 - PDL1 positive
hepatocell cancer (HCC)
early HCC - (neo)adjuvant (NA)
metastatic/advanced hepatocellular cancer (mHCC)
mHCC - (neo)adjuvant (NA)
mHCC - 1st line (L1)
mHCC - 2nd line (L2)
lung cancer : non small cell (NSCLC)
early NSCLC - (neo)adjuvant (NA)
eNSCLC - NA - all population
eNSCLC - NA - EGFR mutant
early NSCLC - 1st line (L1)
locally advanced NSCLC - (neo)adjuvant (NA)
laNSCLC - NA - all population
locally advanced NSCLC - maintenance (M)
laNSCLC - M - all population
laNSCLC - M - EGFR mutant
metastatic/adv NSCLC (mNSCLC) - (neo)adjuvant (NA)
mNSCLC - NA - all population
metastatic/adv NSCLC (mNSCLC) - maintenance (M)
mNSCLC - M - all population
mNSCLC - M - EGFR mutant
mNSCLC - M - EGFR wild type
mNSCLC - M - PDL1 positive
metastatic/advanced NSCLC (mNSCLC) - 1st line (L1)
mNSCLC - L1 - all population
mNSCLC - L1 - EGFR mutant
mNSCLC - L1 - PDL1 negative
mNSCLC - L1 - PDL1 positive
mNSCLC - L1 - TMB>10Mb
non squamous cell - mNSCLC - L1
non squamous - mNSCLC - L1 - all population
non squamous - mNSCLC - L1 - PDL1 positive
non squamous - mNSCLC - L1 - Wild Type (WT)
squamous cell - mNSCLC - L1
squamous - mNSCLC - L1 - all population
squamous - mNSCLC - L1 - PDL1 positive
squamous - mNSCLC - L1 - Wild Type (WT)
metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2)
mNSCLC - L2 - adenocarcinoma cell
mNSCLC - L2 - all population
mNSCLC - L2 - EGFR high
mNSCLC - L2 - EGFR mutant
mNSCLC - L2 - EGFR wild type
mNSCLC - L2 - KRAS mutant
mNSCLC - L2 - KRAS wild type
mNSCLC - L2 - PDL1 negative
mNSCLC - L2 - PDL1 positive
non squamous cell - mNSCLC - L2
non squamous - mNSCLC - L2 - all population
non squamous - mNSCLC - L2 - EGFR mutant
non squamous - mNSCLC - L2 - PDL1 positive
non squamous - mNSCLC - L2 - wild type (WT)
squamous cell - mNSCLC - L2
squamous - mNSCLC - L2 - all population
squamous - mNSCLC - L2 - PDL1 positive
NSCLC adjuvant setting
NSCLC neoadjuvant setting
lung cancer : small cell (SCLC)
Extensive stage SCLC (Es-SCLC)
Extensive stage SCLC (Es-SCLC) - maintenance (M)
Extensive stage SCLC (Es-SCLC) - 1st Line (L1)
Extensive stage SCLC (Es-SCLC) - 2nd line (L2)
limited stage SCLC (ls-SCLC)
limited stage SCLC (ls-SCLC) - maintenance (M)
limited stage SCLC (ls-SCLC) - 2nd Line (L2)
melanoma (ML)
metastatic/adv melanoma (mML)
mML - (neo)adjuvant (NA)
mML - NA - all population
mML - NA - PDL1 positive
mML - 1st line (L1)
mML - L1 - all population
mML - L1 - BRAF mutant
mML - L1 - BRAF wild
mML - 2nd line (L2)
mML - L2 - all population
mML - L2 - BRAF mutant
mesothelioma (MS)
malignant mesothelioma (mMS) - (neo)adjuvant (NA)
malignant mesothelioma (mMS) - 1st line (L1)
malignant mesothelioma (mMS) - 2nd line (L2)
multiple myeloma
multiple myeloma - 1st line (L1)
multiple myeloma - 2nd line (L2)
myofibroblastic tumors
neurofibroma
neutropenia
new pathology
osteosarcoma
ovarian cancer (OC)
metastatic/advanced OC (mOC) - (neo)adjuvant (NA)
metastatic/advanced OC (mOC) - 1st line (L1)
mOC - L1 - all population
mOC - L1 - PDL1 positive
metastatic/advanced OC (mOC) - 2nd line (L2)
metastatic/advanced OC (mOC) - maintenance (M)
pancreatic ductal adenocarcinoma
PIK3CA-related overgrowth spectrum
prostate cancer (PC)
castration-resistant prostate cancer (CRPC)
metastatic (mCRPC) - 1st line (L1)
metastatic (mCRPC) - 2nd line (L2)
metastatic, hormone-sensitive prostate cancer
renal cell cancer (RCC)
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA)
metastatic/advanced RCC (mRCC) - 1st line (L1)
mRCC - L1 - PDL1 negative
mRCC - L1 - PDL1 positive
metastatic/advanced RCC (mRCC) - 2nd line (L2)
sarcomas
thyroid cancer
urothelial cancer (UC) - bladder cancer (BC)
metastatic/advanced UC (mUC) - 1st Line (L1)
mUC - L1 - all population
mUC - L1 - PDL1 positive
metastatic/advanced UC (mUC) - 2nd Line (L2)
mUC - L2 - all population
mUC - L2 - PDL1 positive
metastatic/advanced UC (mUC) - maintenance (M)
mUC - M - all population
mUC - M - PDL1 positive
muscular invasive bladder cancer (MIBC)
MIBC - (neo)adjuvant (NA)
MIBC - NA - all population
MIBC - NA - PDL1 positive
non-muscle-invasive BC (NMIBC)
NMIBC - (neo)adjuvant (NA)
NMIBC - 1st line (L1)
NMIBC - 2nd line (L2)
display ongoing
results:
demonstrated
suggested
inconclusive
safety concern
ongoing study
Nothing for this selection!