| locally advanced (laHNSCC) | metastatic-recurrent HNSCC (mHNSCC) | ||||
| laHNSCC - 1st line (L1) | mHNSCC - L1 - all population | mHNSCC - L1 - PDL1 positive | mHNSCC - L2 - all population | mHNSCC - L2 - PDL1 positive | |
| anti-PD-(L)1 | |||||
| avelumab based treatment | |||||
| avelumab alone | JAVELIN Head and Neck 100 | ||||
| durvalumab based treatment | |||||
| durvalumab alone | EAGLE ... | ||||
| nivolumab based treatment | |||||
| nivolumab alone | CheckMate 141 | ||||
| pembrolizumab based treatment | |||||
| pembrolizumab alone | KEYNOTE-048 ... | KEYNOTE-048 ... KEYNOTE-048 ... | KEYNOTE-040 ... | KEYNOTE-040 ... | |
| pembrolizumab plus 5FU plus platin | KEYNOTE-048 ... | KEYNOTE-048 ... KEYNOTE-048 ... | |||
Study type:
delta: difference in rate or median (if available)
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