Study		Exclusion reasons	Remarks	Reference(s)
Hazan, 2021	case series	no control group		Hazan S et al. medrxiv;2021.07.06.21259924v1 10.1101/2021.07.06.21259924
Nasir, 2020	non randomized controlled trial	no clinically relevant endpoint		Nasir A et al. 10.2139/ssrn.3734478
Cadegiani -Iver, 2020	observational study	other	unappropriated control group	Cadegiani FA medrxiv https://doi.org/10.1101/2020.10.31.20223883
IFORS (Pott-Junior), 2020	randomized controlled trial	other	The article has been retracted by Toxicology Reports	Pott-Junior H Toxicol Rep 2021;8:505-510. 10.1016/j.toxrep.2021.03.003
Elgazzar - treatment, 2020	randomized controlled trial	other	withdrawal of the publication	Elgazzar A et al. 10.21203/rs.3.rs-100956/v2
Niaee (vs placebo), 2020	randomized controlled trial	other	On 8 October 2021 and 9 October 2021, two articles were published by subject-matter experts outlining concerns about various aspects of the study and, in particular, calling into question the randomization of participants. The authors and publishing journal have been alerted to these issues, and this note will be updated with any new information related to the publication.	Niaee MS et al. researchsquare 10.21203/rs.3.rs-109670/v1 Niaee MS et al. Asian Pacific Journal of Tropical Medicine 10.4103/1995-7645.318304

Study

Exclusion reasons

Remarks

Reference(s)

case series

no control group

Hazan S et al. medrxiv;2021.07.06.21259924v1 10.1101/2021.07.06.21259924

non randomized controlled trial

no clinically relevant endpoint

Nasir A et al. 10.2139/ssrn.3734478

observational study

other

unappropriated control group

Cadegiani FA medrxiv https://doi.org/10.1101/2020.10.31.20223883

randomized controlled trial

other

The article has been retracted by Toxicology Reports

Pott-Junior H Toxicol Rep 2021;8:505-510. 10.1016/j.toxrep.2021.03.003

randomized controlled trial

other

withdrawal of the publication

Elgazzar A et al. 10.21203/rs.3.rs-100956/v2

randomized controlled trial

other

On 8 October 2021 and 9 October 2021, two articles were published by subject-matter experts outlining concerns about various aspects of the study and, in particular, calling into question the randomization of participants. The authors and publishing journal have been alerted to these issues, and this note will be updated with any new information related to the publication.

Niaee MS et al. researchsquare 10.21203/rs.3.rs-109670/v1

Niaee MS et al. Asian Pacific Journal of Tropical Medicine 10.4103/1995-7645.318304