Table Graph
   

ivermectin - versus control - for COVID-19 mild to moderate pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.32 [0.10, 1.07]< 10%2 studies (2/-)96.7 %some concernnot evaluable moderatecrucial-
deaths 0.26 [0.09, 0.75]< 10%4 studies (4/-)99.4 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.77 [0.28, 2.12]< 187%2 studies (2/-)69.3 %some concernnot evaluable moderateimportant-
clinical improvement 1.89 [1.06, 3.38]> 10%1 study (1/-)98.4 %NAnot evaluable important-
clinical improvement (7-day) 1.28 [0.61, 2.70]> 191%2 studies (2/-)74.5 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.89 [1.06, 3.38]> 10%1 study (1/-)98.4 %NAnot evaluable important-
hospital discharge 1.20 [0.73, 1.98]> 10%1 study (1/-)76.3 %NAnot evaluable important-
mechanical ventilation 0.39 [0.13, 1.16]< 10%2 studies (2/-)95.5 %some concernnot evaluable moderateimportant-
viral clearance 0.92 [0.77, 1.09]> 10%1 study (1/-)17.3 %NAnot evaluable important-
viral clearance by day 7 0.91 [0.77, 1.08]> 10%2 studies (2/-)13.7 %lownot evaluable highimportant-
ICU admission 0.84 [0.39, 1.78]< 10%2 studies (2/-)67.9 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 2.14 [0.21, 21.56]< 10%2 studies (2/-)26.0 %some concernnot evaluable moderateimportant-
adverse events 1.97 [0.55, 7.04]< 136%3 studies (3/-)15.0 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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