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Non replicating viral vector - versus vaccines - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

hospitalization 6.70 [4.60, 9.76]< 10%1 study (-/1)0.0 %NAnot evaluable important-

safety endpoints 00

adverse events 1.14 [0.89, 1.46]< 10%2 studies (2/-)14.7 %NAnot evaluable non important-
intracranial hemorrhage 1.81 [0.25, 12.86]< 10%4 studies (3/1)27.8 %NAnot evaluable non important-
ischemic stroke 1.58 [0.24, 10.40]< 10%4 studies (3/1)31.8 %NAnot evaluable non important-
Myocardial infarction 2.32 [0.45, 12.09]< 10%5 studies (4/1)15.9 %NAnot evaluable non important-
pulmonary embolism 1.81 [0.25, 12.86]< 10%4 studies (3/1)27.8 %NAnot evaluable non important-
serious adverse events (SAE), any 1.53 [0.25, 9.36]< 10%1 study (1/-)32.3 %NAnot evaluable non important-
venous thromboembolism 1.82 [0.23, 14.13]< 10%3 studies (3/-)28.5 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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