patient subgroup...
age >= 55 yr age >= 65 yr critical disease omicron variant BA.1 (B.1.1.529) solid organ transplant recipients subjects at risk
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
Immunostimulants drugs - versus control - for COVID 19 hospitalized
pdf
xlsx
method
abbreviations
Outcome
Relative effect 95%CI
LoD
Trt. better when
I2
k (RCT/OBS)
Bayesian probability
Overall ROB
Publication bias
Degree of certainty
Endpoint importance
Published MA
efficacy endpoints 00 death D28 0.87 [0.77, 0.99]< 1 31% 38 studies (38/-) 98.4 % some concern critical moderate crucial - death or transfer to ICU 0.89 [0.56, 1.42]< 1 42% 2 studies (2/-) 68.6 % high not evaluable low crucial - deaths 0.88 [0.79, 0.97]< 1 29% 66 studies (66/-) 99.6 % some concern critical moderate crucial 1 deaths (time to event analysis only) 0.87 [0.68, 1.11]< 1 27% 11 studies (11/-) 87.1 % some concern low moderate crucial - clinical deterioration 0.86 [0.73, 1.00]< 1 0% 9 studies (9/-) 97.1 % some concern not evaluable moderate important - clinical improvement 1.08 [0.97, 1.20]> 1 32% 17 studies (17/-) 91.0 % some concern low moderate important - clinical improvement (14-day) 1.37 [0.69, 2.72]> 1 56% 4 studies (4/-) 81.3 % some concern not evaluable moderate important - clinical improvement (28-day) 1.61 [0.96, 2.70]> 1 67% 6 studies (6/-) 96.3 % some concern serious moderate important - clinical improvement (7-day) 1.10 [0.80, 1.51]> 1 35% 4 studies (4/-) 72.6 % some concern not evaluable moderate important - clinical improvement (time to event analysis only) 1.10 [0.96, 1.26]> 1 28% 11 studies (11/-) 91.9 % low critical high important - death or ventilation 0.94 [0.87, 1.02]< 1 54% 10 studies (10/-) 91.7 % some concern low moderate important - hospital discharge 1.09 [0.99, 1.19]> 1 48% 10 studies (10/-) 96.7 % some concern low moderate important - hospitalization 1.00 [0.14, 7.34]< 1 0% 1 study (1/-) 50.0 % NA not evaluable important - mechanical ventilation 0.88 [0.74, 1.04]< 1 9% 14 studies (14/-) 93.2 % some concern critical moderate important 1 mechanical ventilation (time to event analysis only) 0.97 [0.62, 1.52]< 1 0% 2 studies (2/-) 55.5 % some concern not evaluable moderate important - radiologic improvement (14-day) 2.33 [0.45, 12.00]> 1 0% 1 study (1/-) 84.4 % NA not evaluable important - Recovery (time to event analysis only) 1.02 [0.81, 1.28]> 1 0% 1 study (1/-) 56.7 % NA not evaluable important - viral clearance 2.80 [1.05, 7.48]> 1 87% 7 studies (7/-) 98.0 % some concern not evaluable moderate important - viral clearance (time to event analysis only) 1.56 [0.40, 6.09]> 1 90% 2 studies (2/-) 73.9 % some concern not evaluable moderate important - viral clearance by day 14 1.37 [0.12, 16.35]> 1 97% 6 studies (6/-) 59.8 % some concern not evaluable moderate important - viral clearance by day 7 1.45 [0.97, 2.15]> 1 66% 6 studies (6/-) 96.6 % some concern not evaluable moderate important - ICU admission 0.60 [0.41, 0.88]< 1 0% 7 studies (7/-) 99.6 % some concern not evaluable moderate non important - off oxygenation 1.65 [0.05, 50.02]> 1 81% 2 studies (2/-) 61.1 % high not evaluable low non important - recovery 1.12 [0.97, 1.28]> 1 7% 4 studies (4/-) 94.3 % low not evaluable high non important - safety endpoints 00 composite safety outcome 1.56 [0.78, 3.11]< 1 0% 1 study (1/-) 10.3 % NA not evaluable important - serious adverse events 1.16 [0.98, 1.36]< 1 12% 10 studies (10/-) 3.9 % some concern low moderate important - superinfection 0.77 [0.06, 9.89]< 1 76% 2 studies (2/-) 57.8 % high not evaluable low important - adverse events 1.14 [0.92, 1.40]< 1 0% 7 studies (7/-) 11.3 % some concern serious moderate non important -
LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias;
suggested: nominally statistically significant but without a strict control of overall risk of type 1 error;
inconclusive: not nominally statistically significant;
safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies;
published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE.
Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.