All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID 19 hospitalized - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
Pandit, 2021 0.95 [0.02; 50.33]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
1.86 [0.62 ; 5.58 ] Kalil (ACTT-3), 2021, Pandit, 2021, Shashi Bhushan, 2021 3 0% 1,258 moderate not evaluable deathsdetailed results Darazam, 2021 1.21 [0.65; 2.25]
Darazam (COVIFERON Interferon beta-1a), 2021 0.31 [0.07; 1.25]
Darazam (COVIFERON Interferon beta-1b), 2021 0.52 [0.14; 1.92]
Fu, 2020 1.00 [0.02; 51.66]
Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
Li, 2021 1.04 [0.02; 53.73]
Pandit, 2021 0.95 [0.02; 50.33]
Rahmani, 2020 0.29 [0.05; 1.56]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
SOLIDARITY (interferon), 2020 1.16 [0.96; 1.40]
Synairgen SG016, 2020 0.16 [0.01; 3.31]
Wang, 2020 1.00 [0.02; 52.54]
1.11 [0.94 ; 1.32 ] Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Fu, 2020, Kalil (ACTT-3), 2021, Li, 2021, Pandit, 2021, Rahmani, 2020, Shashi Bhushan, 2021, SOLIDARITY (interferon), 2020, Synairgen SG016, 2020, Wang, 2020 12 0% 5,995 moderate low deaths (time to event analysis only)detailed results Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
1.74 [0.51 ; 5.93 ] Kalil (ACTT-3), 2021 1 0% 969 NA not evaluable clinical deteriorationdetailed results Li, 2021 0.52 [0.02; 15.78]
Synairgen SG016, 2020 0.50 [0.18; 1.38]
Wang, 2020 1.00 [0.02; 52.54]
0.52 [0.20 ; 1.35 ] Li, 2021, Synairgen SG016, 2020, Wang, 2020 3 0% 243 moderate not evaluable clinical improvementdetailed results Darazam, 2021 1.37 [0.88; 2.13]
Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12]
Kalil (ACTT-3), 2021 0.99 [0.87; 1.13]
Li, 2021 1.76 [1.10; 2.81]
Shashi Bhushan, 2021 0.68 [0.21; 2.20]
Synairgen SG016, 2020 2.32 [1.07; 5.04]
1.42 [1.00 ; 2.03 ] Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Kalil (ACTT-3), 2021, Li, 2021, Shashi Bhushan, 2021, Synairgen SG016, 2020 6 67% 1,515 moderate serious clinical improvement (14-day)detailed results Kalil (ACTT-3), 2021 1.01 [0.79; 1.29]
Li, 2021 2.86 [1.24; 6.62]
Pandit, 2021 8.77 [0.94; 81.67]
Shashi Bhushan, 2021 0.68 [0.21; 2.20]
1.54 [0.69 ; 3.39 ] Kalil (ACTT-3), 2021, Li, 2021, Pandit, 2021, Shashi Bhushan, 2021 4 68% 1,344 moderate not evaluable clinical improvement (28-day)detailed results Li, 2021 4.26 [1.10; 16.44]
Synairgen SG016, 2020 3.15 [1.39; 7.14]
3.42 [1.70 ; 6.88 ] Li, 2021, Synairgen SG016, 2020 2 0% 195 moderate not evaluable clinical improvement (7-day)detailed results Li, 2021 1.83 [0.41; 8.14]
Shashi Bhushan, 2021 1.91 [1.03; 3.53]
1.90 [1.07 ; 3.35 ] Li, 2021, Shashi Bhushan, 2021 2 0% 316 moderate not evaluable clinical improvement (time to event analysis only)detailed results Darazam, 2021 1.37 [0.88; 2.13]
Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12]
Darazam (COVIFERON Interferon beta-1b), 2021 1.42 [0.63; 3.18]
Kalil (ACTT-3), 2021 0.99 [0.87; 1.13]
Li, 2021 1.76 [1.10; 2.81]
Rahmani, 2020 3.41 [1.33; 8.73]
1.55 [1.07 ; 2.24 ] Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Kalil (ACTT-3), 2021, Li, 2021, Rahmani, 2020 6 71% 1,379 moderate serious death or ventilationdetailed results SOLIDARITY (interferon), 2020 1.05 [0.90; 1.23]
Synairgen SG016, 2020 0.38 [0.09; 1.63]
0.83 [0.35 ; 1.93 ] SOLIDARITY (interferon), 2020, Synairgen SG016, 2020 2 46% 4,100 moderate not evaluable hospital dischargedetailed results Rahmani, 2020 3.44 [0.64; 18.49]
Synairgen SG016, 2020 1.63 [0.61; 4.35]
1.97 [0.84 ; 4.60 ] Rahmani, 2020, Synairgen SG016, 2020 2 0% 167 moderate not evaluable hospitalizationdetailed results Jagannathan, 2020 1.00 [0.14; 7.34]
1.00 [0.14 ; 7.34 ] Jagannathan, 2020 1 0% 120 NA not evaluable mechanical ventilationdetailed results Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.27; 3.67]
Darazam (COVIFERON Interferon beta-1b), 2021 1.00 [0.27; 3.67]
Li, 2021 0.52 [0.02; 15.78]
Rahmani, 2020 0.29 [0.05; 1.56]
0.74 [0.34 ; 1.62 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Li, 2021, Rahmani, 2020 4 0% 240 moderate not evaluable viral clearance detailed results Jagannathan, 2020 0.81 [0.56; 1.18]
Li, 2021 7.68 [0.91; 65.15]
Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
1.98 [0.76 ; 5.13 ] Jagannathan, 2020, Li, 2021, Pandit, 2021, Shashi Bhushan, 2021 4 79% 495 moderate not evaluable viral clearance (time to event analysis only)detailed results Jagannathan, 2020 0.81 [0.56; 1.18]
Li, 2021 1.74 [1.10; 2.75]
1.17 [0.56 ; 2.48 ] Jagannathan, 2020, Li, 2021 2 84% 216 moderate not evaluable viral clearance by day 14detailed results Li, 2021 1.74 [0.71; 4.29]
Pandit, 2021 10.23 [1.12; 93.35]
Shashi Bhushan, 2021 0.00 [0.00; 0.01]
0.38 [0.00 ; 46.74 ] Li, 2021, Pandit, 2021, Shashi Bhushan, 2021 3 98% 1,453 moderate not evaluable viral clearance by day 7detailed results Li, 2021 2.20 [0.95; 5.10]
Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
2.52 [1.55 ; 4.09 ] Li, 2021, Pandit, 2021, Shashi Bhushan, 2021 3 0% 375 moderate not evaluable ICU admissiondetailed results Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.21; 4.71]
Darazam (COVIFERON Interferon beta-1b), 2021 0.46 [0.11; 1.94]
Rahmani, 2020 0.37 [0.14; 1.00]
0.49 [0.24 ; 1.00 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Rahmani, 2020 3 0% 146 moderate not evaluable recoverydetailed results Synairgen SG016, 2020 2.19 [1.03; 4.67]
2.19 [1.03 ; 4.67 ] Synairgen SG016, 2020 1 0% 101 NA not evaluable related SAE (TRSAE)detailed results Wang, 2020 2.04 [0.07; 63.93]
2.04 [0.07 ; 63.93 ] Wang, 2020 1 0% 48 NA not evaluable serious adverse eventsdetailed results Jagannathan, 2020 1.00 [0.14; 7.34]
Pandit, 2021 0.95 [0.02; 50.33]
0.99 [0.17 ; 5.88 ] Jagannathan, 2020, Pandit, 2021 2 0% 159 moderate not evaluable superinfectiondetailed results Rahmani, 2020 0.18 [0.02; 1.59]
0.18 [0.02 ; 1.59 ] Rahmani, 2020 1 0% 66 NA not evaluable adverse eventsdetailed results Jagannathan, 2020 1.33 [0.63; 2.78]
Pandit, 2021 1.68 [0.47; 5.97]
Wang, 2020 3.57 [0.93; 13.72]
1.67 [0.94 ; 2.97 ] Jagannathan, 2020, Pandit, 2021, Wang, 2020 3 0% 207 moderate not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-26 19:56 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 95,94,90,91
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290