lopinavir/ritonavir in COVID-19 severe or critically - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias deathsdetailed results Cao, 2020 0.71 [0.36; 1.40]
REMAP-CAP (lopinavir/ritonavir only), 2020 0.83 [0.65; 1.06]
0.81 [0.65 ; 1.03 ] Cao, 2020, REMAP-CAP (lopinavir/ritonavir only), 2020 2 0% 844 moderate not evaluable deaths (time to event analysis only)detailed results REMAP-CAP (lopinavir/ritonavir only), 2020 0.83 [0.65; 1.06]
0.83 [0.65 ; 1.06 ] REMAP-CAP (lopinavir/ritonavir only), 2020 1 0% 645 NA not evaluable clinical improvementdetailed results Cao, 2020 1.31 [0.94; 1.83]
1.31 [0.94 ; 1.83 ] Cao, 2020 1 0% NA not evaluable clinical improvement (14-day)detailed results Cao, 2020 1.94 [1.09; 3.48]
REMAP-CAP (lopinavir/ritonavir only), 2020 0.85 [0.64; 1.12]
1.23 [0.55 ; 2.76 ] Cao, 2020, REMAP-CAP (lopinavir/ritonavir only), 2020 2 84% 844 moderate not evaluable clinical improvement (28-day)detailed results Cao, 2020 1.59 [0.84; 3.03]
1.59 [0.84 ; 3.03 ] Cao, 2020 1 0% 199 NA not evaluable clinical improvement (7-day)detailed results Cao, 2020 3.16 [0.62; 16.06]
3.16 [0.62 ; 16.06 ] Cao, 2020 1 0% 199 NA not evaluable clinical improvement (time to event analysis only)detailed results Cao, 2020 1.31 [0.94; 1.83]
1.31 [0.94 ; 1.83 ] Cao, 2020 1 0% NA not evaluable hospital dischargedetailed results REMAP-CAP (lopinavir/ritonavir only), 2020 0.83 [0.69; 1.00]
0.83 [0.69 ; 1.00 ] REMAP-CAP (lopinavir/ritonavir only), 2020 1 0% 645 NA not evaluable serious adverse eventsdetailed results Cao, 2020 0.52 [0.27; 1.01]
REMAP-CAP (lopinavir/ritonavir only), 2020 1.57 [0.70; 3.49]
0.88 [0.30 ; 2.58 ] Cao, 2020, REMAP-CAP (lopinavir/ritonavir only), 2020 2 77% 811 moderate not evaluable 0.5 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-11-04 22:21 +01:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 91
- treatments: 509
- roots T: 290