All patients
age >= 55 yr age >= 60 yr age >= 65 yr autoimmune disease corticosteroids: no corticosteroids: yes critical disease invasive ventilation no oxygen needed non invasive oxygen omicron variant BA.1 (B.1.1.529) severe disease solid organ transplant recipients subjects at risk
anti-inflammatoty and immuno-therapy in COVID-19 mild to moderate - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
Pandit, 2021 0.95 [0.02; 50.33]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
1.01 [0.15 ; 6.93 ] COL-COVID (Pascual-Figal), 2021, Pandit, 2021, Shashi Bhushan, 2021 3 0% 392 moderate not evaluable deathsdetailed results COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
Fu, 2020 1.00 [0.02; 51.66]
Pandit, 2021 0.95 [0.02; 50.33]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
1.01 [0.18 ; 5.69 ] COL-COVID (Pascual-Figal), 2021, Fu, 2020, Pandit, 2021, Shashi Bhushan, 2021 4 0% 472 moderate not evaluable clinical deteriorationdetailed results COL-COVID (Pascual-Figal), 2021 0.38 [0.09; 1.58]
0.38 [0.09 ; 1.58 ] COL-COVID (Pascual-Figal), 2021 1 0% 103 NA not evaluable clinical improvementdetailed results Shashi Bhushan, 2021 0.68 [0.21; 2.20]
0.68 [0.21 ; 2.20 ] Shashi Bhushan, 2021 1 0% 242 NA not evaluable clinical improvement (14-day)detailed results Pandit, 2021 8.77 [0.94; 81.67]
Shashi Bhushan, 2021 0.68 [0.21; 2.20]
2.03 [0.17 ; 24.32 ] Pandit, 2021, Shashi Bhushan, 2021 2 75% 281 moderate not evaluable clinical improvement (7-day)detailed results Shashi Bhushan, 2021 1.91 [1.03; 3.53]
1.91 [1.03 ; 3.53 ] Shashi Bhushan, 2021 1 0% 222 NA not evaluable mechanical ventilationdetailed results COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
0.24 [0.01 ; 5.41 ] COL-COVID (Pascual-Figal), 2021 1 0% 103 NA not evaluable radiologic improvement (14-day)detailed results Rashad (CLARI vs SoC), 2021 2.87 [1.56; 5.28]
2.87 [1.56 ; 5.28 ] Rashad (CLARI vs SoC), 2021 1 0% 198 NA not evaluable viral clearance detailed results Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
2.69 [1.48 ; 4.87 ] Pandit, 2021, Shashi Bhushan, 2021 2 0% 281 moderate not evaluable viral clearance by day 14detailed results Pandit, 2021 10.23 [1.12; 93.35]
Shashi Bhushan, 2021 0.00 [0.00; 0.01]
0.18 [0.00 ; 435.69 ] Pandit, 2021, Shashi Bhushan, 2021 2 98% 1,359 moderate not evaluable viral clearance by day 7detailed results Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
2.69 [1.48 ; 4.87 ] Pandit, 2021, Shashi Bhushan, 2021 2 0% 281 moderate not evaluable ICU admissiondetailed results COL-COVID (Pascual-Figal), 2021 0.47 [0.08; 2.69]
0.47 [0.08 ; 2.69 ] COL-COVID (Pascual-Figal), 2021 1 0% 103 NA not evaluable serious adverse eventsdetailed results COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
Pandit, 2021 0.95 [0.02; 50.33]
0.40 [0.03 ; 4.70 ] COL-COVID (Pascual-Figal), 2021, Pandit, 2021 2 0% 142 moderate not evaluable adverse eventsdetailed results COL-COVID (Pascual-Figal), 2021 1.72 [0.73; 4.08]
Pandit, 2021 1.68 [0.47; 5.97]
1.71 [0.84 ; 3.49 ] COL-COVID (Pascual-Figal), 2021, Pandit, 2021 2 0% 142 moderate not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-24 20:42 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 90
- treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525
- roots T: 290