metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mUC - L1 - all population metastatic/advanced UC (mUC) - 1st Line (L1) mUC - L1 - all population
versus gemcitabine plus platin
	atezolizumab alone
	IMvigor-130 (At-arm B vs Ch-armC), 2020 Lancet 2020; 395:1547-1557 NCT02807636	RCT	mUC - L1 - all population	atezolizumab (B)	chemotherapy (C) gemcitabine plus platine	patients with untreated locally advanced or metastatic urothelial carcinoma	360 / 400	some concern	inconclusive	inconclusive 2 % increase in deaths (OS) (PE) statistically significant 62 % decrease in objective responses (ORR)
mUC - L2 - all population metastatic/advanced UC (mUC) - 2nd Line (L2) mUC - L2 - all population
versus Standard of Care (SoC)
	atezolizumab alone
	IMvigor-211 (all population), 2018 Lancet 2018;391:748-757 Eur Urol 2021 Apr 23;S0302-2838(21)00230-X. NCT02302807	RCT	mUC - L2 - all population	atezolizumab	chemotherapy	patients with locally advanced or metastatic urothelial bladder cancer (UBC) who have progressed during or following a platinum-containing regimen patients had received no more than two previous lines of therapy and had progressed during or following one or more platinum-containing regimens for metastatic urothelial carcinoma (or neoadjuvant or adjuvant therapy with progression)	467 / 464	some concern	suggested	suggested 15 % decrease in deaths (OS) (PE) suggested 18 % decrease in deaths (OS) (extension)
mUC - L2 - PDL1 positive metastatic/advanced UC (mUC) - 2nd Line (L2) mUC - L2 - PDL1 positive
versus Standard of Care (SoC)
	atezolizumab alone
	IMvigor-211 (PDL1>5%), 2018 Lancet 2018;391:748-757 Eur Urol 2021 Apr 23;S0302-2838(21)00230-X. NCT02302807	RCT	mUC - L2 - PDL1 positive	atezolizumab	chemotherapy	patients with locally advanced or metastatic urothelial bladder cancer (UBC) who have progressed during or following a platinum-containing regimen patients had received no more than two previous lines of therapy and had progressed during or following one or more platinum-containing regimens for metastatic urothelial carcinoma (or neoadjuvant or adjuvant therapy with progression)	116 / 118	some concern	inconclusive	inconclusive 13 % decrease in deaths (OS) (PE)
	IMvigor-211 (PDL1>1%), 2018 Lancet 2018;391:748-757 Eur Urol 2021 Apr 23;S0302-2838(21)00230-X. NCT02302807	RCT	mUC - L2 - PDL1 positive	atezolizumab	chemotherapy	patients with locally advanced or metastatic urothelial bladder cancer (UBC) who have progressed during or following a platinum-containing regimen patients had received no more than two previous lines of therapy and had progressed during or following one or more platinum-containing regimens for metastatic urothelial carcinoma (or neoadjuvant or adjuvant therapy with progression	316 / 309	some concern	suggested	inconclusive 13 % decrease in deaths (OS) (PE)
MIBC - NA - all population muscular invasive bladder cancer (MIBC) MIBC - (neo)adjuvant (NA) MIBC - NA - all population
versus no additional treatment
	atezolizumab alone
	IMvigor-010, 2021 Urologe A 2016; 55:1491-1493 ESMO Immuno-Oncology Virtual Congress 2020 (9-12 December) Lancet Oncol 2021 Apr;22(4):525-537. The Lancet Oncology NCT02450331	RCT	MIBC - (neo)adjuvant (NA)	atezolizumab	observation	patients aged 18 years or older and had histologically confirmed muscle-invasiveurothelial carcinoma of either the bladder or the upper tract as Adjuvant Therapy (Participants With High-Risk Muscle-Invasive Urothelial Carcinoma)	406 / 403	some concern	inconclusive	inconclusive 11 % decrease in events or deaths (EFS) (PE)