Study study type PathologyT1T0Patientssample sizesROB Results

es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA) breast cancer - triple negative es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA)

versus non active control
avelumab alone
A-Brave, 2024
  NCT02926196
RCTes-BC - Triple negatif (TNBC) - (neo)adjuvant (NA)avelumabcontrolPatiennts at High-risk Triple Negative Breast Cancer after completion of standard treatment with curative intent including surgery and neoadjuvant/adjuvant chemotherapy.-/-NA
suggested
  • suggested 34 % decrease in deaths (OS)
  • inconclusive 18 % decrease in RFS/DFS (PE)
  • inconclusive 19 % decrease in RFS/DFS (PE)
One year adjuvant avelumab versus control does not significantly improve DFS in high-risk TNBC patients. Nevertheless, the secondary enpoind OS was significanlty improved with avelumab vs control.