meta
|
evidence
oncology
Living systematic review and meta-analysis
breast cancer - triple negative
1
breast cancer - triple negative metastatic
mBC - Triple negative (TNBC) - (neo)adjuvant (NA)
mBC - Triple negative (TNBC) - 1st Line (L1)
1
la/mBC - TNBC - L1 - all population
8
la/mBC - TNBC - L1 - PDL1 positive
5
mBC-Triple negative (TNBC) - 2nd Line (L2)
3
la/mBC - TNBC - L2 - all population
3
la/mBC - TNBC - L2 - PDL1 positive
5
es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA)
2
es-BC - TNBC - NA - all population
5
es-BC - TNBC - NA - PDL1 positive
1
es-BC - Triple negatif (TNBC) - 1st line (L1)
All treatments
immune chekpoint inhibitors
anti-PD-(L)1
atezolizumab based treatment
atezolizumab plus SoC
pembrolizumab based treatment
pembrolizumab alone
poly ADP-ribose polymerase (PARP) inhibitor
olaparib
versus all
vs chemotherapy
vs Standard of Care (SoC)
vs placebo plus SoC
vs non active control
vs placebo
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
summary
GRADE
treatment
patients
risk of bias
overview
deaths (OS) (extension)
pCR
AE leading to death (grade 5)
SAE (any grade)
hepatitis (Autoimmune) AE (grade 3-4)
Abdominal pain AE (grade 3-4)
Alopecia AE (grade 3-4)
Anaemia AE (grade 3-4)
Arthralgia AE (grade 3-4)
Back pain AE (grade 3-4)
Blood creatinine increased AE (grade 3-4)
Constipation AE (grade 3-4)
Cough AE (grade 3-4)
Diarrhoea AE (grade 3-4)
Dry skin AE (grade 3-4)
Dyspnoea AE (grade 3-4)
Epistaxis AE (grade 3-4)
Fatigue AE (grade 3-4)
Febrile neutropenia AE (grade 3-4)
Headache AE (grade 3-4)
Hyperthyroidism AE (grade 3-4)
Hypophysitis AE (grade 3-4)
Hypothyroidism AE (grade 3-4)
Increase AST AE (grade 3-4)
Increased ALT AE (grade 3-4)
Infusion-related reaction AE (grade 3-4)
Injury, poisoning and procedure AE (grade 3-4)
Leucopenia AE (grade 3-4)
Myalgia AE (grade 3-4)
Nausea AE (grade 3-4)
Neutropenia AE (grade 3-4)
Peripheral neuropathy AE (grade 3-4)
Pneumonitis AE (grade 3-4)
Rash AE (grade 3-4)
Stomatitis AE (grade 3-4)
Thrombocytopenia AE (grade 3-4)
Vomiting AE (grade 3-4)
numeric
bar chart
forest plot
medians
frequency on treatment
benefit risk analysis
Study
study type
RCT
OBS
RCT + OBS
Pathology
T1
T0
Patients
sample sizes
ROB
Results
×
delta: difference in rate or median (if available)
×
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