metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
la/mBC - TNBC - L1 - all population breast cancer - triple negative breast cancer - triple negative metastatic mBC - Triple negative (TNBC) - 1st Line (L1) la/mBC - TNBC - L1 - all population
versus nab-paclitaxel plus placebo
	nab-paclitaxel plus toripalimab
	TORCHLIGHT, 2024 Nat Med 2024; 30:249-256-. NCT04085276	RCT	la/mBC - TNBC - L1 - all population	toripalimab and nab-paclitaxel	placebo and nab-P	Patients aged at least 18 years with histologically confirmed TNBC, previously untreated or no more than one previous systemic chemotherapy regimen for stage IV or locally advanced TNBC that is not amenable to surgery	353 / 178	low	inconclusive	suggested 31 % decrease in deaths (OS) suggested 23 % decrease in progression or deaths (PFS) (PE)
la/mBC - TNBC - L1 - PDL1 positive breast cancer - triple negative breast cancer - triple negative metastatic mBC - Triple negative (TNBC) - 1st Line (L1) la/mBC - TNBC - L1 - PDL1 positive
versus nab-paclitaxel plus placebo
	nab-paclitaxel plus toripalimab
	TORCHLIGHT PDL 1 positive population, 2024 Nat Med 2024; 30:249-256-. NCT04085276	RCT	la/mBC - TNBC - L1 - PDL1 positive	toripalimab and nab-paclitaxel	placebo and nab-P	Patients aged at least 18 years with histologically confirmed TNBC, previously untreated or no more than one previous systemic chemotherapy regimen for stage IV or locally advanced TNBC that is not amenable to surgery	200 / 100	low	conclusif	suggested 38 % decrease in deaths (OS) demonstrated 35 % decrease in progression or deaths (PFS) (PE) The addition of toripalimab to nab-P provided a significant improvement in PFS for PD-L1-positive patients with metastatic or recurrent TNBC with an acceptable safety profile.