Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

COLCOVID
  NCT04328480		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
640/639 inconclusive
  • inconclusive 17 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
Gaitan-Duarte (Rosuvastatin plus colchicine)
  NCT04359095		 RCTColchicine plus rosuvastatinstandard of careCOVID 19 hospitalizedsome concern
161/162 inconclusive
  • inconclusive 19 % decrease in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
Horby
  NCT04381936		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
5610/5730 inconclusive
    RECOVERY (colchicine)
          NCT04381936    		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
    		5610/5730 inconclusive
    • inconclusive 1 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
    GRECCO-19
          NCT04326790    		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
    		55/50 suggested
    • suggested 89 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
    Salehzadeh
          IRCT20200418047126N1    		 RCTcolchicineplaceboCOVID 19 hospitalizedsome concern
    		50/50 inconclusive
      Comparing two groups showed significantly different only in the duration of hospitalized (P<0.05). Although in colchicine group dyspnea was improved more rapid than the placebo group, but it was not meaningful.

      COVID-19 mild to moderate meta-analysis

      COL-COVID (Pascual-Figal)
              NCT04350320      		 RCTcolchicinestandard of careCOVID-19 mild to moderatesome concern
      		52/51 inconclusive
        5 studies excluded by filtering options (2 RCT / 3 OBS)

        PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
        Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

         

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