Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 severe or critically meta-analysis

Munch (COVID-STEROID)
  NCT04348305		 RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
16/14 no results
    CAPE-COVID
          NCT02517489    		 RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
    		76/73 inconclusive
    • inconclusive 29 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
    REMAP-CAP, fixed 7-day course
          NCT02735707    		 RCTHydrocortisonestandard of careCOVID-19 severe or criticallyhigh
    		143/108 safety concern
    • inconclusive 43 % increase in clinical improvement (PE) but with a low degree of certainty due to high risk of bias
    • statistically significant 1.7-fold increase in death or ventilation but with a low degree of certainty due to high risk of bias

    PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
    Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

     

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