Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

SPRINTER
  NCT04732949		 RCTSNG001 inhaled interferon betaplaceboCOVID 19 hospitalizedNA
309/314 inconclusive
  • inconclusive 2 % increase in clinical improvement (time to event analysis only),Recovery (time to event analysis only) (PE)
  • inconclusive 6 % increase in hospital discharge (PE)
Li
  ChiCTR2000029638		 RCTrecombinant super-compound interferon rSIFN-coIFN alphaCOVID 19 hospitalizedsome concern
48/48 conclusif
  • demonstrated 76 % increase in clinical improvement,clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 1.9-fold increase in clinical improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 3.3-fold increase in clinical improvement (28-day) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 74 % increase in viral clearance (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias
Synairgen SG016
  NCT04385095		 RCTSNG001 inhaled interferon betaplaceboCOVID 19 hospitalizedsome concern
50/51 suggested
  • suggested 1.3-fold increase in clinical improvement with a moderate degree of certainty due to some concern in risk of bias
  • suggested 2.2-fold increase in clinical improvement (28-day) with a moderate degree of certainty due to some concern in risk of bias

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

 

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