Isradipine (versus unexposed)

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14351
R56798		 Darcie, 2004 Cesarean late pregnancy prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.91 [0.54;6.78] C 28/39   8/14 36 39
ref
S14370
R56904		 Wide-Swensson, 1995 Cesarean section 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.31 [0.52;3.30] C 14/47   11/45 25 47
ref
Total 2 studies 1.49 [0.71;3.15] 61 86
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Darcie, 2004Darcie, 2004 1.91[0.54; 6.78]363935%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Wide-Swensson, 1995Wide-Swensson, 1995 1.31[0.52; 3.30]254765%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: lowROB reporting: moderate Total (2 studies) I2 = 0% 1.49[0.71; 3.15]61860.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.91[0.54; 6.78]3639 -NADarcie, 2004 1 case control studiescase control studies 0 RCTRCT 1.31[0.52; 3.30]2547 -NAWide-Swensson, 1995 1 Type of controls unexposed, sickunexposed, sick 1.49[0.71; 3.15]61860%NADarcie, 2004 Wide-Swensson, 1995 2 Tags Adjustment   - No  - No 1.91[0.54; 6.78]3639 -NADarcie, 2004 1   - Randomisation  - Randomisation 1.31[0.52; 3.30]2547 -NAWide-Swensson, 1995 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.49[0.71; 3.15]61860%NADarcie, 2004 Wide-Swensson, 1995 2 All studiesAll studies 1.49[0.71; 3.15]61860%NADarcie, 2004 Wide-Swensson, 1995 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.49[0.71; 3.15]61860%NADarcie, 2004 Wide-Swensson, 1995 20.510.01.0