Acebutolol (versus unexposed) updated on 12-17-2024

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14340
R56736		 Yassen, 1992 Acute fetal distress (lasting alteration of fetal heart recording tracings: micro-oscillating appearance, bradycardia) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 30.33 [1.39;660.79] C 6/11   0/11 6 11
ref
Total 1 studies 30.33 [1.39;660.79] 6 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yassen, 1992Yassen, 1992 30.33[1.39; 660.79]6110%ROB confusion: criticalROB selection: unclearROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 30.33[1.39; 660.79]611 -NAYassen, 1992 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 30.33[1.39; 660.79]611 -NAYassen, 1992 1 Tags Adjustment   - No  - No 30.33[1.39; 660.79]611 -NAYassen, 1992 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 30.33[1.39; 660.79]611 -NAYassen, 1992 1 MatchedMatched 30.33[1.39; 660.79]611 -NAYassen, 1992 1 All studiesAll studies 30.33[1.39; 660.79]611 -NAYassen, 1992 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale30.33[1.39; 660.79]611 -NAYassen, 1992 10.510.01.0