Acebutolol (versus unexposed) updated on 12-17-2024

Neonatal bradycardia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14340
R56737		 Yassen, 1992 Neonatal bradycardia (< 100beats /min) with cyanosis during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 21.00 [0.97;453.94] C 5/11   0/11 5 11
ref
Total 1 studies 21.00 [0.97;453.94] 5 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yassen, 1992Yassen, 1992 21.00[0.97; 453.94]5110%ROB confusion: criticalROB selection: unclearROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 21.00[0.97; 453.94]511 -NAYassen, 1992 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 21.00[0.97; 453.94]511 -NAYassen, 1992 1 Tags Adjustment   - No  - No 21.00[0.97; 453.94]511 -NAYassen, 1992 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 21.00[0.97; 453.94]511 -NAYassen, 1992 1 MatchedMatched 21.00[0.97; 453.94]511 -NAYassen, 1992 1 All studiesAll studies 21.00[0.97; 453.94]511 -NAYassen, 1992 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale21.00[0.97; 453.94]511 -NAYassen, 1992 10.510.01.0