Carvedilol (versus unexposed) updated on 12-17-2024

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17236
R72137		 Kubota - Carvedilol, 2023 Vacuum or forceps during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.63 [0.03;11.39] C 0/32   6/263 6 32
ref
Total 1 studies 0.63 [0.03;11.39] 6 32
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kubota - Carvedilol, 2023Kubota - Carvedilol, 2023 0.63[0.03; 11.39]6320%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: critical0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 1 Tags Adjustment   - No  - No 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 1 All studiesAll studies 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.63[0.03; 11.39]632 -NAKubota - Carvedilol, 2023 10.510.01.0