Carvedilol (versus unexposed) updated on 12-17-2024

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14076
R55412		 Tanaka, 2016 Preterm births during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 2.02 [0.56;7.31] C 4/13   18/100 22 13
ref
Total 1 studies 2.02 [0.56;7.31] 22 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tanaka, 2016Tanaka, 2016 2.02[0.56; 7.31]22130%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.02[0.56; 7.31]2213 -NATanaka, 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.02[0.56; 7.31]2213 -NATanaka, 2016 1 Tags Adjustment   - No  - No 2.02[0.56; 7.31]2213 -NATanaka, 2016 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 2.02[0.56; 7.31]2213 -NATanaka, 2016 1 All studiesAll studies 2.02[0.56; 7.31]2213 -NATanaka, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.02[0.56; 7.31]2213 -NATanaka, 2016 10.510.01.0