Methotrexate (Post-conception)

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10694
R39507		 Cooper (Controls exposed to other treatment, sick), 2014 Central nervous system defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 3.35 [0.16;71.81] C
excluded (control group) 		0/23   2/379 2 23
ref
S8721
R29484		 Cooper (Controls unexposed, sick), 2014 Central nervous system defects 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 7.58 [0.15;391.43] C 0/23   0/171 0 23
ref
Total 1 studies 7.58 [0.15;391.43] 0 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper (Controls unexposed, sick), 2014Cooper, 2014 1 7.58[0.15; 391.43]0230%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Indications   - Inflammatory diseases  - Inflammatory diseases 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 All studiesAll studies 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10694

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.35[0.16; 71.81]223 -NACooper (Controls exposed to other treatment, sick), 2014 10.510.01.0