Methotrexate (Post-conception)

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10694
R39513		 Cooper (Controls exposed to other treatment, sick), 2014 Gastrointestinal defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 3.35 [0.16;71.81] C
excluded (control group) 		0/23   2/379 2 23
ref
S8721
R29490		 Cooper (Controls unexposed, sick), 2014 Gastrointestinal defects 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 2.51 [0.10;63.53] C 0/23   1/171 1 23
ref
Total 1 studies 2.51 [0.10;63.53] 1 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper (Controls unexposed, sick), 2014Cooper, 2014 1 2.51[0.10; 63.53]1230%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 Indications   - Inflammatory diseases  - Inflammatory diseases 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 All studiesAll studies 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10694

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.51[0.10; 63.53]123 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.35[0.16; 71.81]223 -NACooper (Controls exposed to other treatment, sick), 2014 10.510.01.0