Methotrexate (Post-conception)

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10694
R39516		 Cooper (Controls exposed to other treatment, sick), 2014 Genital defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 1.10 [0.06;19.89] C
excluded (control group) 		0/23   7/379 7 23
ref
S8721
R29493		 Cooper (Controls unexposed, sick), 2014 Genital defects 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 7.58 [0.15;391.43] C 0/23   0/171 0 23
ref
Total 1 studies 7.58 [0.15;391.43] 0 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper (Controls unexposed, sick), 2014Cooper, 2014 1 7.58[0.15; 391.43]0230%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 Indications   - Inflammatory diseases  - Inflammatory diseases 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 All studiesAll studies 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10694

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.58[0.15; 391.43]-23 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.10[0.06; 19.89]723 -NACooper (Controls exposed to other treatment, sick), 2014 10.510.01.0