Methotrexate (Post-conception)

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10694
R39498		 Cooper (Controls exposed to other treatment, sick), 2014 Fetal death 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 8.93 [1.55;51.55] C
excluded (control group) 		2/23   4/379 6 23
ref
S8721
R29475		 Cooper (Controls unexposed, sick), 2014 Fetal death 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 3.18 [0.54;18.62] 2/23   4/171 6 23
ref
S6775
R19128		 Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 Stillbirths at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 2.46 [0.34;17.57] C
excluded (control group) 		2/188   2/459 4 188
ref
S10347
R37907		 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Stillbirths at least 1st trimester prospective cohort unexposed, disease free Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 11.89 [1.07;131.82] C 2/188   1/1,107 3 188
ref
Total 2 studies 5.05 [1.21;21.03] 9 211
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper (Controls unexposed, sick), 2014Cooper, 2014 1 3.18[0.54; 18.62]62365%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Weber-Schoendorfer (Controls unexposed, disease free), 2014Weber-Schoendorfer, 2014 2 11.89[1.07; 131.82]318835%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 5.05[1.21; 21.03]92110.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.05[1.21; 21.03]92110%NACooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 11.89[1.07; 131.82]3188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 unexposed, sickunexposed, sick 3.18[0.54; 18.67]623 -NACooper (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 11.89[1.07; 131.82]3188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1   - Yes  - Yes 3.18[0.54; 18.67]623 -NACooper (Controls unexposed, sick), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 5.05[1.21; 21.03]92110%NACooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 2 Indications   - Inflammatory diseases  - Inflammatory diseases 5.05[1.21; 21.03]92110%NACooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 2 MatchedMatched 11.89[1.07; 131.82]3188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 All studiesAll studies 5.05[1.21; 21.03]92110%NACooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10694, 6775

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale11.89[1.07; 131.82]3188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls 3.18[0.54; 18.67]623 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.04[1.36; 18.67]102110%NACooper (Controls exposed to other treatment, sick), 2014 Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 20.510.01.0