Methotrexate (Post-conception)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6775
R19171		 Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 Elective termination of pregnancy at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 4.55 [2.81;7.36] C
excluded (control group) 		49/188   33/459 82 188
ref
S10347
R37911		 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed, disease free Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 7.40 [4.50;12.20] 49/188   49/1,107 98 188
ref
S6666
R19085		 Vinet, 2013 Induced abortions in women with rheumatoid arthritis 3 months (or more) before pregnancy or during pregnancy excluded nested case control unexposed, sick Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched MTX less than 6 months before pregnancy 0.47 [0.25;0.89]
excluded (exposition period) 		12/1,284   100/4,683 112 1,284
ref
Total 1 studies 7.40 [4.49;12.18] 98 188
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weber-Schoendorfer (Controls unexposed, disease free), 2014Weber-Schoendorfer, 2014 1 7.40[4.50; 12.20]981880%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Tags Adjustment   - No  - No 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Indications   - Inflammatory diseases  - Inflammatory diseases 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 MatchedMatched 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 All studiesAll studies 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6775

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.40[4.49; 12.18]98188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.55[2.81; 7.36]82188 -NAWeber-Schoendorfer (Controls exposed to other treatment, sick), 2014 10.510.01.0