Methotrexate (Post-conception)

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7205
R20460		 Howren, 2020 Small for gestational age (less than the 10th percentile of gestational age- and sex-specific weights) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 1.73 [0.35;8.51] -/-   -/6,064 - -
ref
Total 1 studies 1.73 [0.35;8.53] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howren, 2020Howren, 2020 1.73[0.35; 8.51]--0%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.73[0.35; 8.53]-- -NAHowren, 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.73[0.35; 8.53]-- -NAHowren, 2020 1 Tags Adjustment   - Yes  - Yes 1.73[0.35; 8.53]-- -NAHowren, 2020 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 1.73[0.35; 8.53]-- -NAHowren, 2020 1 Indications   - Inflammatory diseases  - Inflammatory diseases 1.73[0.35; 8.53]-- -NAHowren, 2020 1 All studiesAll studies 1.73[0.35; 8.53]-- -NAHowren, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.73[0.35; 8.53]-- -NAHowren, 2020 10.510.01.0