Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg - Medication and Pregnancy KB

Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Major congenital malformations

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17647 R74531	Berard (150 mg), 2019	Major congenital malformation (according ICD-9 and 10)	1st trimester	nested case control	unexposed (general population or NOS)	Adjustment: Yes	1.08 [0.87;1.34]	92/913 19,396/225,686	19,488	913		ref
S17642 R74416	Molgaard-Nielsen (150 mg), 2013	Major birth defects	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes	0.99 [0.82;1.20]	107/4,082 25,159/968,236	25,266	4,082		ref
S17653 R74568	Jick (92% received the single 150-mg dose preparation), 1999	Congenital anomaly	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.07 [0.37;3.10] ^C	4/234 26/1,629	30	234		ref
					Total	3 studies	1.03 [0.89;1.19]		44,784	5,229
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: 150 mg; 2: 150 mg; 3: 92% received the single 150-mg dose preparation;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded