Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17647
R74533		 Berard (150 mg), 2019 Eye malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.03 [0.33;3.25] 3/913   725/225,686 728 913
ref
Total 1 studies 1.03 [0.33;3.23] 728 913
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Berard (150 mg), 2019Berard, 2019 1 1.03[0.33; 3.25]7289130%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: 150 mg;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.03[0.33; 3.23]728913 -NABerard (150 mg), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.33; 3.23]728913 -NABerard (150 mg), 2019 1 Tags Adjustment   - Yes  - Yes 1.03[0.33; 3.23]728913 -NABerard (150 mg), 2019 1 All studiesAll studies 1.03[0.33; 3.23]728913 -NABerard (150 mg), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.33; 3.23]728913 -NABerard (150 mg), 2019 10.510.01.0