Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17653
R74571
Jick (92% received the single 150-mg dose preparation), 1999 Cleft lip or palate 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.32 [0.09;57.20] C 0/234   1/1,629 1 234
ref
Total 1 studies 2.32 [0.09;57.20] 1 234
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jick (92% received the single 150-mg dose preparation), 1999Jick, 1999 1 2.32[0.09; 57.20]12340%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: 92% received the single 150-mg dose preparation;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.32[0.09; 57.20]1234 -NAJick (92% received the single 150-mg dose preparation), 1999 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.32[0.09; 57.20]1234 -NAJick (92% received the single 150-mg dose preparation), 1999 1 Tags Adjustment   - No  - No 2.32[0.09; 57.20]1234 -NAJick (92% received the single 150-mg dose preparation), 1999 1 All studiesAll studies 2.32[0.09; 57.20]1234 -NAJick (92% received the single 150-mg dose preparation), 1999 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.32[0.09; 57.20]1234 -NAJick (92% received the single 150-mg dose preparation), 1999 10.510.01.0