Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17651
R74563		 Inman (single 150mg dose), 1994 Therapeutic termination of pregnancy during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.43 [0.66;3.10] C 11/58   27/192 38 58
ref
Total 1 studies 1.43 [0.66;3.10] 38 58
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Inman (single 150mg dose), 1994Inman, 1994 1 1.43[0.66; 3.10]38580%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: single 150mg dose;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.66; 3.10]3858 -NAInman (single 150mg dose), 1994 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.43[0.66; 3.10]3858 -NAInman (single 150mg dose), 1994 1 Tags Adjustment   - No  - No 1.43[0.66; 3.10]3858 -NAInman (single 150mg dose), 1994 1 All studiesAll studies 1.43[0.66; 3.10]3858 -NAInman (single 150mg dose), 1994 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.43[0.66; 3.10]3858 -NAInman (single 150mg dose), 1994 10.510.01.0