Benzodiazepines (Psy and mixed indications) - Medication and Pregnancy KB

Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Club foot / Talipes equinovarus

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15464 R63605	Blotière - Clonazepam (Other indications), 2019	Talipes equinovarus	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	1.14 [0.16;8.12] ^C	1/980 1,677/1,875,733	1,678	980		ref
S15587 R64147	Källén - BZDs, 2013	Pes equinovarus	early pregnancy	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Not specified	0.96 [0.31;2.24]	5/2,537 -/1,575,847	-	2,537		ref
S15535 R63831	Czeizel - Diazepam, 2003	Clubfoot	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched	1.00 [0.70;1.60]	-/- 2,429/-	-	-		ref
					Total	3 studies	1.00 [0.69;1.45]		1,678	3,517
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Other indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)