Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15587
R64169		 Källén - BZDs, 2013 Hypoglycaemia 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified 1.38 [1.19;1.60] 194/-   -/- - -
ref
S15310
R62972		 Laegreid a - BZDs, 1992 Neonatal hypoglycemia throughout pregnancy prospective cohort unexposed, disease free Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 1.73 [0.03;91.21] C 0/17   0/29 0 17
ref
Total 2 studies 1.38 [1.19;1.60] 0 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén - BZDs, 2013Källén - BZDs, 2013 1.38[1.19; 1.60]--100%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Laegreid a - BZDs, 1992Laegreid a - BZDs, 1992 1.73[0.03; 91.21]0170%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.38[1.19; 1.60]-170.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.38[1.19; 1.60]-170%NAKällén - BZDs, 2013 Laegreid a - BZDs, 1992 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.38[1.19; 1.60]-170%NAKällén - BZDs, 2013 Laegreid a - BZDs, 1992 2 Tags Adjustment   - No  - No 1.73[0.03; 91.21]-17 -NALaegreid a - BZDs, 1992 1   - Yes  - Yes 1.38[1.19; 1.60]-- -NAKällén - BZDs, 2013 1 BZD Coexposure   - No (among psychiatric (ATD and/or p ...  - No (among psychiatric (ATD and/or psychotropics) medications) 1.73[0.03; 91.21]-17 -NALaegreid a - BZDs, 1992 1   - Not specified  - Not specified 1.38[1.19; 1.60]-- -NAKällén - BZDs, 2013 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 1.73[0.03; 91.21]-17 -NALaegreid a - BZDs, 1992 1 All studiesAll studies 1.38[1.19; 1.60]-170%NAKällén - BZDs, 2013 Laegreid a - BZDs, 1992 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.38[1.19; 1.60]185170%NAKällén - BZDs, 2013 Laegreid a - BZDs, 1992 20.510.01.0