Benzodiazepines (Psy and mixed indications) - Medication and Pregnancy KB

Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Elective/induced termination of pregnancy

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18301 R77074	Ban (Controls unexposed, disease free), 2012	Termination of pregnancy	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications)	2.20 [1.90;2.60] excluded (control group)	654/3,392 -/-	-	3,392		ref
S18302 R77077	Ban (Controls unexposed, sick), 2012	Termination of pregnancy	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications)	1.90 [1.60;2.30]	654/3,392 -/-	-	3,392		ref
S15322 R63048	Ornoy - BZDs, 1998	Induced abortions	at least 1st trimester	prospective cohort	unexposed, disease free	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	3.50 [2.10;5.90]	65/460 20/424	85	460		ref
					Total	2 studies	2.45 [1.36;4.43]		85	3,852
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18301

Umbrella review (other published meta-analyses)