Tricyclic antidepressants updated on 07-01-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11118
R41086		 Dandjinou, 2019 Gestational diabetes mellitus during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: TCA only 1.47 [1.22;1.77] 143/971   20,762/228,982 20,905 971
ref
Total 1 studies 1.47 [1.22;1.77] 20,905 971
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dandjinou, 2019Dandjinou, 2019 1.47[1.22; 1.77]20,9059710%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 1 Tags Adjustment   - Yes  - Yes 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 1 Monotherapy   - TCA only  - TCA only 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 1 All studiesAll studies 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.47[1.22; 1.77]20,905971 -NADandjinou, 2019 10.510.01.0