| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18161 R76387 |
Chan (Controls exposed to SSRIs), 2024 | Atrial septal defect (ASD) | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: TCA only |
1.59 [0.70;3.60] C excluded (control group) |
9/322 17/956 | 26 | 322 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18156 R76341 |
Chan (Controls unexposed, general pop), 2024 | Atrial septal defect (ASD) | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes Monotherapy: TCA only |
2.77 [1.43;5.38] excluded (control group) |
9/322 4,755/462,377 | 4,764 | 322 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18157 R76352 |
Chan (Controls unexposed, sick), 2024 | Atrial septal defect (ASD) | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: TCA only Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified | 0.90 [0.22;3.72] | 2/181 55/4,413 | 57 | 181 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10938 R40734 |
Ban (Controls unexposed, disease free), 2014 | Atrial septal defect | 1st trimester | retrospective cohort (claims database) | unexposed, disease free | Adjustment: Yes Monotherapy: TCA only | 1.43 [0.54;3.83] | -/2,428 -/325,294 | - | 2,428 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11322 R41708 |
Louik, 2014 | Atrial septal defects | 1st trimester | case control | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: no or not specified | 1.50 [0.60;3.60] | 6/38 1,136/9,715 | 1,142 | 38 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 1.34 [0.74;2.45] | 1,199 | 2,647 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, sick; 2: Controls unexposed, disease free;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 18161, 18156