Tricyclic antidepressants updated on 07-01-2025

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13260
R51070		 Wall-Wieler, 2020 Ectopic pregnancy early pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.44 [1.00;2.06] 34/1,037   2,255/105,751 2,289 1,037
ref
Total 1 studies 1.44 [1.00;2.07] 2,289 1,037
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wall-Wieler, 2020Wall-Wieler, 2020 1.44[1.00; 2.06]2,2891,0370%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 1 Tags Adjustment   - Yes  - Yes 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 1 Monotherapy   - no or not specified  - no or not specified 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 1 All studiesAll studies 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.44[1.00; 2.07]2,2891,037 -NAWall-Wieler, 2020 10.510.01.0