Tricyclic antidepressants updated on 07-01-2025

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10930
R40617		 Davis, 2007 Fetal distress 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 5.90 [0.36;96.15] C 0/136   47/75,957 47 136
ref
Total 1 studies 5.90 [0.36;96.15] 47 136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Davis, 2007Davis, 2007 5.90[0.36; 96.15]471360%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.90[0.36; 96.15]47136 -NADavis, 2007 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.90[0.36; 96.15]47136 -NADavis, 2007 1 Tags Adjustment   - No  - No 5.90[0.36; 96.15]47136 -NADavis, 2007 1 Monotherapy   - no or not specified  - no or not specified 5.90[0.36; 96.15]47136 -NADavis, 2007 1 All studiesAll studies 5.90[0.36; 96.15]47136 -NADavis, 2007 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.90[0.36; 96.15]47136 -NADavis, 2007 10.510.01.0