Tricyclic antidepressants updated on 07-01-2025

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11223
R41297		 Ban (Controls exposed to SSRIs), 2012 Perinatal death (stillbirth or neonatal death within the first 28 days postpartum) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 1.04 [0.64;1.68] C
excluded (control group) 		22/4,349   69/14,191 91 4,349
ref
S11221
R41290		 Ban (Controls unexposed, disease free), 2012 Perinatal death (stillbirth or neonatal death within the first 28 days postpartum) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes Monotherapy: TCA only 1.60 [0.90;2.90]
excluded (control group) 		22/4,349   -/- - 4,349
ref
S11222
R41294		 Ban (Controls unexposed, sick), 2012 Perinatal death (stillbirth or neonatal death within the first 28 days postpartum) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: TCA only Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.20 [0.50;2.70] 22/4,349   -/- - 4,349
ref
Total 1 studies 1.20 [0.52;2.79] 0 4,349
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, sick), 2012Ban, 2012 1 1.20[0.50; 2.70]-4,3490%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 1 Tags Adjustment   - Yes  - Yes 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 1 Monotherapy   - TCA only  - TCA only 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 1 All studiesAll studies 1.20[0.52; 2.79]-4,349 -NABan (Controls unexposed, sick), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11223, 11221

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[0.89; 2.87]134,349 -NABan (Controls unexposed, disease free), 2012 1 unexposed, sick controlsunexposed, sick controls 1.20[0.52; 2.79]134,349 -NABan (Controls unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.04[0.64; 1.68]914,349 -NABan (Controls exposed to SSRIs), 2012 10.510.01.0