Tricyclic antidepressants updated on 07-01-2025

Very low Apgar score (< 5) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10935
R40672		 Simon (Controls exposed to SSRIs), 2002 Apgar score at 1 minute ≤5 during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.42 [0.21;0.83] C
excluded (control group) 		14/209   27/185 41 209
ref
S10936
R40688		 Simon (Controls unexposed, NOS), 2002 Apgar score at 1 minute ≤5 during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: TCA only 1.16 [0.50;2.71] 14/209   13/209 27 209
ref
Total 1 studies 1.16 [0.50;2.70] 27 209
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Simon (Controls unexposed, NOS), 2002Simon, 2002 1 1.16[0.50; 2.71]272090%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 Tags Adjustment   - Yes  - Yes 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 MatchedMatched 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 Monotherapy   - TCA only  - TCA only 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 All studiesAll studies 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10935

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.16[0.50; 2.70]27209 -NASimon (Controls unexposed, NOS), 2002 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.21; 0.83]41209 -NASimon (Controls exposed to SSRIs), 2002 10.510.01.0